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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Pattern of deposition of stainless steel welding fume particles inhaled into the respiratory systems of Sprague-Dawley rats exposed to a novel welding fume generating system.
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Pattern of deposition of stainless steel welding fume particles inhaled into the respiratory systems of Sprague-Dawley rats exposed to a novel welding fume generating system.

机译：吸入Sprague-Dawley大鼠呼吸系统的不锈钢焊接烟尘颗粒的沉积模式，暴露于新型焊接烟尘产生系统中。

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In order to investigate occupational diseases related to welding fume exposure, such as nasal septum perforation, pneumoconiosis and manganese intoxication, we built a welding fume exposure system that included a welding fume generator, exposure chamber and fume collector. The fume concentrations in the exposure chamber were monitored every 15 min during a 2-h exposure. Fume (mg/m(3)) concentrations of major metals, including Fe, Mn, Cr, and Ni were found to be consistently maintained. An acute inhalation toxicity study was conducted by exposing male Sprague-Dawley rats to the welding fumes generated in this apparatus by stainless steel arc welding. The rats were exposed in the inhalation chamber to a welding fume with a concentration of 62 mg/m(3) total suspended particulates for 4 h. Animals were sacrificed at 4 h and at 1, 3, 7, 10, and 14 days after exposure. Histopathological examinations were conducted on the animals' upper respiratory tracts, including the nasal pathway and the conducting airway, and on the gas exchange region including the alveolar ducts, alveolar sacs, and alveoli. Diameters of fume particles varied from 0.02 to 0.81 microm and were distributed log normally, with a mean diameter of 0.1 microm and geometric standard deviation of 1.42. Rats exposed to the welding fume for 4 h did not show any significant respiratory system toxicity. The mean particle diameter of 0.1 microm resulted in little adsorption of the welding fume particles in the upper respiratory tract. Particle adsorption took place principally in the lower respiratory tracts, including bronchioles, alveolar ducts, alveolar sacs, and alveoli.
机译：为了调查与焊接烟雾暴露有关的职业病，例如鼻中隔穿孔，尘肺和锰中毒，我们建立了焊接烟雾暴露系统，其中包括焊接烟雾发生器，暴露室和烟雾收集器。在2小时的暴露过程中，每15分钟监测一次暴露室内的烟气浓度。发现包括铁，锰，铬和镍在内的主要金属的烟气（mg / m（3））浓度始终保持不变。急性吸入毒性研究是通过将雄性Sprague-Dawley大鼠暴露于该设备通过不锈钢电弧焊产生的焊接烟雾中进行的。将大鼠在吸入室内暴露于浓度为62 mg / m（3）的总悬浮颗粒物的焊接烟雾中4小时。暴露后4小时和1、3、7、10和14天处死动物。对动物的上呼吸道（包括鼻腔通路和传导气道）以及在包括肺泡管，肺泡囊和肺泡的气体交换区域进行了组织病理学检查。烟雾颗粒的直径从0.02到0.81微米不等，呈对数正态分布，平均直径为0.1微米，几何标准偏差为1.42。暴露于焊接烟雾中4 h的大鼠未显示任何明显的呼吸系统毒性。 0.1微米的平均粒径导致焊烟颗粒在上呼吸道中的吸附很少。颗粒吸附主要发生在下呼吸道，包括细支气管，肺泡管，肺泡囊和肺泡。

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