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首页> 外文期刊>Toxicology mechanisms and methods >The Study of Analgesic Effects and Acute Toxicity of Tripleurospermum disciforme in Rats by Formalin Test
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The Study of Analgesic Effects and Acute Toxicity of Tripleurospermum disciforme in Rats by Formalin Test

机译：福尔马林试验研究三倍体扁桃体对大鼠的镇痛作用和急性毒性

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Previous studies have demonstrated the anti-inflammatory effect of Tripleurospermum disciforme extract in rats with a hind paw edema test. The present study was done to further characterize this anti-inflammatory effect using a formalin test in the intact rats, specifically studying the analgesic effect as well as its toxicity effect by determination of LD50 using graded oral doses of T. disciforme. The effects of graded doses of T. disciforme were investigated following intraperitoneal (IP) administration. Forty-eight rats were used in six groups of studies. The first group (control) received formalin 2.5%, the second group formalin 2.5% + saline, and the third group formalin 2.5% and morphine; three other groups received formalin 2.5% and 15 mg/kg, 30 mg/kg, and 60 mg/kg. After 5, 15, 30, 45, 60 min the pain responses were measured T. disciforme 60 mg/kg had a significant analgesic effect and this effect was equal to morphine 2 mg/kg in the chronic phase of the formalin test. To assess the utility ofT. disciforme, the toxic effect of extract was studied by determination of LD50 using graded oral doses of 50, 500, and 5000 mg/kg of T. disciforme to fasted rats and LD50 was measured after 24, 48, and 72 hours. In conclusion, these studies show that T. disciforme is significantly nontoxic at doses required as analgesic drug and higher doses of T. disciforme could produce significant analgesic effects and confirm its previous significant anti-inflammatory effect.
机译：先前的研究表明，后足爪水肿试验对鼠尾草Tripleurospermum disciforme提取物具有抗炎作用。本研究旨在通过福尔马林测试在完整大鼠中进一步表征该抗炎作用，特别是通过使用分级口服剂量的盘状T.Discforme测定LD50来研究镇痛作用及其毒性作用。腹膜内（IP）给药后研究了T.discforme分级剂量的影响。在六组研究中使用了48只大鼠。第一组（对照组）接受福尔马林2.5％，第二组接受福尔马林2.5％+生理盐水，第三组接受福尔马林2.5％和吗啡;其他三个组分别接受了2.5％和15 mg / kg，30 mg / kg和60 mg / kg的福尔马林。在5、15、30、45、60分钟后，测量了60毫克/千克的门诊T.discforme具有明显的镇痛作用，在福尔马林试验的慢性阶段，该作用相当于吗啡2毫克/千克。评估T的效用。通过使用口服50、500和5000 mg / kg的T.discforme对空腹大鼠进行LD50测定，研究了提取物的毒性作用，并在24、48和72小时后测定了LD50。总之，这些研究表明，作为镇痛药所需的剂量，盘状T. disciforme明显无毒，而更高剂量的盘状T. disciforme可以产生明显的止痛作用，并证实其先前的显着抗炎作用。

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