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首页> 外文期刊>Chemical Physics: A Journal Devoted to Experimental and Theoretical Research Involving Problems of Both a Chemical and Physical Nature >Photoisomerization of green fluorescent protein and the dimensions of the chromophore cavity
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Photoisomerization of green fluorescent protein and the dimensions of the chromophore cavity

机译：绿色荧光蛋白的光异构化和生色团腔的尺寸

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摘要

Green fluorescent protein (GFP) has a fairly large central cavity, which contains the chromophore, however it does not have a shape that is complementary with a planar chromophore. The protein exerts some strain on the chromophore when it is planar and the only reason planar chromophores are found in GFP is due to their delocalized π-electrons. Our calculations show that the protein environment of GFP allows the chromophore some rotational freedom, especially by a hula-twist and in the φ dihedral angle. The excited state, responsible for fluorescence, may therefore the twisted relative to the ground state. However, cis-trans photoisomerization cannot occur by a 180° rotation of the τ dihedral angle.
机译：绿色荧光蛋白（GFP）具有相当大的中心腔，其中包含发色团，但其形状与平面发色团不互补。当蛋白质处于平面状态时，该蛋白质会对发色团施加一定的应变，而在GFP中发现平面发色团的唯一原因是由于它们的离域π电子。我们的计算表明，GFP的蛋白质环境使发色团具有一定的旋转自由度，尤其是通过呼啦扭曲和φ二面角。因此，负责荧光的激发态可能相对于基态发生扭曲。但是，顺反式光异构化不能通过τ二面角旋转180°发生。

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