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首页> 外文期刊>Surface and Interface Analysis: SIA: An International Journal Devoted to the Development and Application of Techniques for the Analysis of Surfaces, Interfaces and Thin Films >The adsorption of bone-related proteins on calcium phosphate ceramic particles with different phase composition and its adsorption kinetics
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The adsorption of bone-related proteins on calcium phosphate ceramic particles with different phase composition and its adsorption kinetics

机译：不同相组成的磷酸钙陶瓷颗粒上骨相关蛋白的吸附及其吸附动力学

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摘要

Calcium phosphate (CaP) ceramics, especially hydroxyapatite and biphasic calcium phosphate (BCP), have attracted significant interest in bone tissue engineering because of their compositional similarities to bone mineral and excellent biocompatibility. The purpose of this study is to investigate the effect of phase compositions of CaP ceramics on their bone morphogenetic protein-2 (BMP-2) adsorption behaviours in phosphate-buffered saline. The BCP material surface probably has more adsorption sites which can adsorb more BMP-2 molecules. Langmuir, Frundlich, and Temkin isotherm models were used to describe the adsorption of BMP-2 onto CaP ceramics. The Langmuir isotherm model fit the equilibrium data better than the Frundlich and Temkin isotherm models. The pseudo-first-order kinetic model is suitable for the description of the adsorption kinetics, and 240min is thought to be the optimal adsorption time. A possible adsorption mechanism has been proposed. The electrostatic interaction plays an important role in the adsorption processes. In addition, the BMP-2 could be adsorbed to the surface which showed slight conformational changes analysed by Fourier transform infrared spectroscopy. Copyright (c) 2016 John Wiley & Sons, Ltd.
机译：磷酸钙（CaP）陶瓷，尤其是羟基磷灰石和双相磷酸钙（BCP），由于其与骨矿物质的组成相似性和出色的生物相容性，在骨组织工程中引起了极大的兴趣。这项研究的目的是研究CaP陶瓷的相组成对其在磷酸盐缓冲液中的骨形态发生蛋白2（BMP-2）吸附行为的影响。 BCP材料表面可能具有更多的吸附位，可以吸附更多的BMP-2分子。 Langmuir，Frundlich和Temkin等温线模型用于描述BMP-2在CaP陶瓷上的吸附。 Langmuir等温线模型比Frundlich和Temkin等温线模型更好地拟合了平衡数据。拟一级动力学模型适合描述吸附动力学，认为240min是最佳吸附时间。已经提出了可能的吸附机理。静电相互作用在吸附过程中起重要作用。此外，BMP-2可以被吸附到表面，该表面通过傅立叶变换红外光谱分析显示出轻微的构象变化。版权所有（c）2016 John Wiley＆Sons，Ltd.

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