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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >No benefits from combining chloroquine with artesunate for three days for treatment of Plasmodium falciparum in Guinea-Bissau.
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No benefits from combining chloroquine with artesunate for three days for treatment of Plasmodium falciparum in Guinea-Bissau.

机译：在几内亚比绍治疗三天后，将氯喹与青蒿琥酯联合使用治疗恶性疟原虫没有任何好处。

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摘要

The use of a combination of chloroquine and artesunate has been suggested for treatment of malaria in Africa. We used concomitant as well as sequential medication with these 2 drugs in relation to each drug separately for children infected with Plasmodium falciparum in Guinea-Bissau from March 2000 to November 2001. By block-randomization, 474 children with symptomatic malaria were divided into 4 groups and given either a total of 8 mg artesunate per kg bodyweight for 3 d, a total of 25 mg chloroquine base per kg bodyweight for 3 d, both drugs concomitantly for 3 d, or both drugs in sequence. All children were followed weekly for 5 weeks. On day 28, parasites had been detected in 40% of the children who were treated with artesunate only compared with 21% treated with chloroquine, 20% treated with artesunate in combination with chloroquine, and 16% treated with artesunate and chloroquine in sequence; on day 35 the corresponding percentages were 48%, 29%, 27%, and 24%, respectively. The outcome of the combination of chloroquine and artesunate in the doses studied was similar to the outcome of chloroquine monotherapy regardless of whether the 2 drugs are given concomitantly (relative risk [RR] = 0.93, 95% CI 0.56-1.53, P = 0.76) or in sequence (RR = 0.78, 95% CI 0.47-1.28, P = 0.32). Thus, neither an antagonistic, an additive, or a synergistic effect of the 2 drugs was indicated.
机译：在非洲，已建议使用氯喹和青蒿琥酯的组合治疗疟疾。我们对2000年3月至2001年11月在几内亚比绍感染恶性疟原虫的儿童分别使用了这2种药物的同时用药和顺序用药。通过分组随机分组，将474例有症状疟疾的儿童分为4组并分别给予每公斤体重8毫克青蒿琥酯3天，每公斤体重总计25毫克氯喹碱3天，两种药物同时治疗3天或两种药物依次给药。所有儿童每周接受随访，持续5周。在第28天，按顺序使用青蒿琥酯治疗的儿童中有40％检出了寄生虫，相比之下，用氯喹治疗的儿童为21％，用青蒿琥酯与氯喹组合治疗的儿童为20％，用青蒿琥酯和氯喹治疗的儿童为16％;在第35天，相应的百分比分别为48％，29％，27％和24％。无论是否同时给予2种药物，氯喹和青蒿琥酯联合使用的剂量与氯喹单药治疗的结果相似（相对危险度[RR] = 0.93，95％CI 0.56-1.53​​，P = 0.76）或依序排列（RR = 0.78，95％CI 0.47-1.28，P = 0.32）。因此，两种药物均未显示出拮抗作用，加和作用或协同作用。

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