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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Prevalence of hantavirus antibody in patients with chronic renal disease in Egypt.
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Prevalence of hantavirus antibody in patients with chronic renal disease in Egypt.

机译：埃及慢性肾脏病患者中汉坦病毒抗体的患病率。

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摘要

In Egypt, the etiology of chronic renal failure (CRF) is not well defined. A hospital-based case-control study was initiated in February 1998, to determine whether hantavirus infection is involved in chronic renal disease (CRD) in Egypt. The study enrolled 350 study patients with a history of CRF and 695 matched controls with CRD due to renal calculus or renal cancer, but with normal renal functions. Sera from cases and controls were tested for anti-hantavirus IgG using ELISA with a cell-lysate antigen from Hantaan virus prototype strain 76-118. A demographic questionnaire was completed for each study participant. Five of the 350 cases (1.4%), and seven of the 695 controls (1.0%) were antibody-positive to hantavirus, with a titer > or =1:400. The difference in antibody prevalence between the study cases and the control cases was not statistically significant (P = 0.48). All antibody-positive study cases and controls had been exposed to rodents. Data indicated that in Egypt, hantavirus seroprevalence inCRD patients is low, and hantavirus infections do not appear to be a significant cause of CRF.
机译：在埃及，慢性肾功能衰竭（CRF）的病因尚不明确。 1998年2月启动了一项基于医院的病例对照研究，以确定汉坦病毒感染是否与埃及的慢性肾病（CRD）有关。该研究招募了350名具有CRF病史的研究患者和695名因肾结石或肾癌而具有正常肾功能的CRD对照。使用来自汉坦病毒原型菌株76-118的细胞溶解抗原，使用ELISA对来自病例和对照的血清进行抗汉坦病毒IgG的测试。为每个研究参与者完成了人口统计学调查表。 350例病例中有5例（1.4％），695例对照中有7例（1.0％）对汉坦病毒呈抗体阳性，效价>或= 1：400。研究病例与对照组之间的抗体流行率差异无统计学意义（P = 0.48）。所有抗体阳性的研究病例和对照都暴露于啮齿动物。数据表明，在埃及，CRD患者的汉坦病毒血清阳性率很低，汉坦病毒感染似乎并不是引起CRF的重要原因。

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