...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Changes in the nasal carriage of drug-resistant Streptococcus pneumoniae in urban and rural Vietnamese schoolchildren.
【24h】

Changes in the nasal carriage of drug-resistant Streptococcus pneumoniae in urban and rural Vietnamese schoolchildren.

机译：越南城市和农村学龄儿童耐药肺炎链球菌鼻腔输送的变化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Studying the antimicrobial drug resistance of nasopharyngeal or nasal carriage isolates of Streptococcus pneumoniae in children is likely to have predictive potential for invasive isolates. Streptococcus pneumoniae nasal carriage was studied in 1422 Vietnamese children. Forty-six percent of 536 isolates showed reduced susceptibility to penicillin and 7% showed intermediate susceptibility to ceftriaxone; and 50% of 518 isolates showed resistance to erythromycin. All isolates were sensitive to levofloxacin and gatifloxacin. Urban and suburban children were significantly more likely to carry drug-resistant isolates than rural children. Rates of non-susceptibility to penicillin and erythromycin increased significantly in the rural province Khanh Hoa in 2003/2004 compared with rates obtained in 1997. An emerging clone of penicillin non-susceptible S. pneumoniae of serogroup 15 was identified, which was widely distributed in addition to the pandemic clones Spain(23F)-1 and Taiwan(19F)-14. Although resistanceto fluoroquinolones was not observed, 6 (18%) of 34 isolates had a Lys137Asn mutation in the parC gene. This study shows that drug resistance is increasing in carriage isolates of S. pneumoniae in rural areas in Vietnam owing to spread of pandemic and emerging resistant clones.
机译：研究儿童肺炎链球菌鼻咽或鼻支架分离株的抗菌药物耐药性可能对侵入性分离株具有预测潜力。对1422名越南儿童进行了肺炎链球菌鼻支架研究。 536株分离株中有46％对青霉素的敏感性降低，而7％对头孢曲松的中等敏感性。 518株分离株中有50％表现出对红霉素的抗性。所有分离株均对左氧氟沙星和加替沙星敏感。与农村儿童相比，城市和郊区儿童携带耐药菌株的可能性要高得多。与1997年获得的比率相比，农村省庆和市在2003/2004年对青霉素和红霉素的不敏感率显着增加。鉴定出了一个新出现的血清群15的不敏感青霉素链球菌肺炎链球菌，该克隆广泛分布于除了大流行的克隆西班牙（23F）-1和台湾（19F）-14。尽管未观察到对氟喹诺酮类药物的耐药性，但34个分离株中有6个（18％）在parC基因中具有Lys137Asn突变。这项研究表明，由于大流行和新出现的耐药性克隆的传播，越南农村地区肺炎链球菌携带的分离株的耐药性正在增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号