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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Immunotherapy of american cutaneous leishmaniasis in Venezuela during the period 1990-99.
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Immunotherapy of american cutaneous leishmaniasis in Venezuela during the period 1990-99.

机译：1990-99年期间，委内瑞拉美国皮肤利什曼病的免疫治疗。

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摘要

Of a total of 11532 Venezuelan patients with American cutaneous leishmaniasis (ACL) receiving immunotherapy with a combined vaccine containing heat-killed Leishmania promastigotes and bacille Calmette-Guerin (BCG) during the period 1990-99, we evaluated 5341 from 4 widely separated geographical states. Clinical healing varied from 91.2 to 98.7%, with an average of 95.7%. Adverse reactions were mild and limited to those associated with BCG vaccination alone. Immunotherapy failures in 143 patients included 54.5% with typical localized ulcers and 45.5% with non-mucosal intermediate cutaneous leishmaniasis (ICL). Less than 2% of the patients in this study had lesions suggestive of ICL. The disproportionately large number of immunotherapy failures in the ICL group suggests that it should not be used as monotherapy in this group. Weaker reactivity to purified protein derivative in immunotherapy failures, while not statistically significant in the small group reported here, suggests the possibility that thesepatients develop a relatively torpid immune response. The high percentage of clinical cures achieved with immunotherapy, associated with few secondary effects and low cost, support the use of immunotherapy in the routine treatment of localized ACL.
机译：在1990年至99年期间，共有11532名委内瑞拉患有皮肤性利什曼病（ACL）的美国皮肤病患者接受了包含热杀死的利什曼原虫前鞭毛体和杆菌卡梅特-格林（BCG）联合疫苗的免疫疗法，我们评估了4341个不同地理位置的州。临床治愈率从91.2到98.7％不等，平均为95.7％。不良反应轻微，仅限于与卡介苗接种有关的不良反应。 143例患者的免疫治疗失败包括54.5％的典型局部溃疡和45.5％的非粘膜中间皮肤利什曼病（ICL）。这项研究中少于2％的患者有提示ICL的病变。在ICL组中，免疫疗法失败的比例不成比例，这表明该组不应将其用作单一疗法。在免疫治疗失败时，对纯化蛋白衍生物的反应性较弱，尽管在此处报道的小组研究中无统计学意义，但表明这些患者可能会出现相对较差的免疫反应。免疫疗法取得的高临床治愈率，与次要作用和低成本相关，支持在局部ACL的常规治疗中使用免疫疗法。

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