Performance evaluation of automated depolarization analysis for detecting clinically unsuspected malaria in endemic countries.

Dromigny JA; Jambou R; Scott CS; Perrier Gros Claude JD

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Performance evaluation of automated depolarization analysis for detecting clinically unsuspected malaria in endemic countries.

机译：自动去极化分析的性能评估，用于在流行国家中检测出临床上未怀疑的疟疾。

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This prospective study evaluated the efficiency of automated depolarization analysis for recognition of unsuspected malaria by haemozoin detection during routine full blood count (FBC) screening of 676 randomly selected out-patients in a malaria hypoendemic area of Senegal. An additional 123 patients with clinically suspected malaria were studied for comparison. Of the 799 samples, 648 (81.1%) were categorized as malaria-negative, 83 (10.4%) as malaria-positive, and 68 as treated (early convalescence) or subclinical malaria (indirect evidence of infection). At a discrimination level of one or more atypical pigment-containing monocytes (PCM), negative and positive agreement was found to be 95.6% and 91.6% respectively for all malaria-negative and parasite-positive samples combined. Increasing the discriminator to two or more PCM events improved the overall agreement to 97.5%. Multivariate analysis showed that the only significant risk factor for the presence of PCM (odds ratio>200) was malaria infection. In the randomly selected group of 676 patients, 41 unsuspected cases of malaria infection were detected using the panel of reference diagnostic tests, and 37 (90.2%) of these had atypical PCM. The detection of clinically unrecognized malaria infection as part of a routine FBC procedure is a potentially useful extended application for laboratories in countries with endemic malaria.

机译：这项前瞻性研究评估了在塞内加尔疟疾低流行地区的676名随机选择的门诊病人的常规全血细胞计数（FBC）筛查过程中，通过血细胞生成素检测对自动去极化分析识别未疑疟疾的效率。对另外123名临床怀疑的疟疾患者进行了研究以进行比较。在799个样本中，有648个（81.1％）被归为疟疾阴性，83个（10.4％）被归为疟疾阳性，有68个被划分为已治疗（早期恢复期）或亚临床疟疾（间接感染证据）。在一个或多个含非典型色素的单核细胞（PCM）的鉴别水平下，所有疟疾阴性和寄生虫阳性样本的总阴性和阳性一致性分别为95.6％和91.6％。将区分器增加到两个或多个PCM事件，使总体一致性提高到97.5％。多变量分析表明，存在PCM（比值> 200）的唯一重要危险因素是疟疾感染。在676例患者的随机选择组中，使用参考诊断测试小组检测到41例未怀疑的疟疾感染病例，其中37例（90.2％）具有非典型PCM。作为常规FBC程序的一部分，对临床上无法识别的疟疾感染的检测对于疟疾流行国家的实验室来说，可能是有用的扩展应用。

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《Transactions of the Royal Society of Tropical Medicine and Hygiene》 |2005年第6期|共10页
作者
Dromigny JA; Jambou R; Scott CS; Perrier Gros Claude JD;
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正文语种 eng
中图分类预防医学、卫生学;
关键词
Malaria; Infection as complication of medical care; Protein-Energy Malnutrition; 疟疾; 蛋白质能量营养不足;

机译：Malaria;Infection as complication of medical care;Protein-Energy Malnutrition;疟疾;蛋白质能量营养不足;

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1. Performance evaluation of automated depolarization analysis for detecting clinically unsuspected malaria in endemic countries. [J] . Dromigny JA, Jambou R, Scott CS, Transactions of the Royal Society of Tropical Medicine and Hygiene . 2005,第6期

机译：自动去极化分析的性能评估，用于在流行国家中检测出临床上未怀疑的疟疾。
2. Automated Detection of Malaria-Associated Pseudoeosinophilia and Abnormal WBC Scattergram by the Sysmex XE-2100 Hematology Analyzer: A Clinical Study with 1,801 Patients and Real-Time Quantitative PCR Analysis in Vivax Malaria-Endemic Area [J] . Yoo Jong-Ha, Song Jaewoo, Lee Kyung-A, American Journal of Tropical Medicine and Hygiene . 2010,第3期

机译：Sysmex XE-2100血液分析仪自动检测与疟疾有关的假性嗜酸性粒细胞增多和异常的WBC散点图：在Vivax疟疾流行地区对1,801名患者进行的临床研究和实时定量PCR分析
3. Automated detection of malaria-associated pseudoeosinophilia and abnormal WBC scattergram by the Sysmex XE-2100 hematology analyzer: a clinical study with 1,801 patients and real-time quantitative PCR analysis in vivax malaria-endemic area. [J] . Yoo JH, Song J, Lee K The American Journal of Tropical Medicine and Hygiene . 2010,第3期

机译：Sysmex XE-2100血液分析仪自动检测与疟疾相关的假嗜酸性粒细胞增多症和WBC散点图异常：这项针对1,801例患者的临床研究，以及实时定量PCR分析在间日疟疾流行地区。
4. Prevention of malaria among nonimmune rotating expatriates when they are back home from endemic countries. [C] . Philippe Guibert Society of Petroleum Engineers International Conference on Health, Safety and Environment in Oil and Gas Exploration and Production . 2004

机译：在流行国家回到家庭时，在非immune旋转外籍人士中预防疟疾。
5. Concept Development, Design, Analysis, and Performance Evaluation of An Automated Computerized Auscultation and Diagnostic System For Respiratory Sound. [D] . Abbas, Ali. 2010

机译：呼吸声自动计算机听诊和诊断系统的概念开发，设计，分析和性能评估。
6. Automated Detection of Malaria-Associated Pseudoeosinophilia and Abnormal WBC Scattergram by the Sysmex XE-2100 Hematology Analyzer: A Clinical Study with 1801 Patients and Real-Time Quantitative PCR Analysis in Vivax Malaria-Endemic Area [O] . Jong-Ha Yoo, Jaewoo Song, Kyung-A Lee, 2010

机译：Sysmex XE-2100血液分析仪自动检测与疟疾有关的假性嗜酸性粒细胞增多和WBC散点图异常：在Vivax疟疾流行地区对1801名患者进行的临床研究和实时定量PCR分析
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Performance evaluation of automated depolarization analysis for detecting clinically unsuspected malaria in endemic countries.

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