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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >The vervet monkey (Chlorocebus aethiops) as an experimental model for Trypanosoma brucei gambiense human African trypanosomiasis: a clinical, biological and pathological study.
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The vervet monkey (Chlorocebus aethiops) as an experimental model for Trypanosoma brucei gambiense human African trypanosomiasis: a clinical, biological and pathological study.

机译：黑长尾猴（Chlorocebus aethiops）作为布氏锥虫人类非洲锥虫病的实验模型：一项临床，生物学和病理学研究。

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It has long been known that the vervet monkey, Chlorocebus (C.) aethiops, can be infected with Trypanosoma rhodesiense, but this model has not been described for T. gambiense. In this study, we report the development of such a model for human African trypanosomiasis. Twelve vervet monkeys infected with T. gambiense developed chronic disease. The duration of the disease ranged between 23 and 612 days (median 89 days) in five untreated animals. Trypanosomes were detected in the blood within the first 10 days post-infection and in the cerebrospinal fluid, with a median delay of 120 days (n = 4, range 28-348 days). Clinical changes included loss of weight, adenopathy, and in some cases eyelid oedema and lethargy. Haematological alterations included decreases in haemoglobin level and transitory decreases in platelet count. Biological modifications included increased gamma globulins and total proteins and decreased albumin. Pathological features of the infection were presence of Mott's cells, inflammatory infiltration of either mononuclear cells or lymphocytes and plasma cells in the brain parenchyma, and astrocytosis. These observations indicate that the development of the disease in vervet monkeys is similar to human T. gambiense infection. We conclude that C. aethiops is a promising experimental primate model for the study of T. gambiense trypanosomiasis.
机译：早就知道，黑长尾猴（Chlorocebus（C.）aethiops）可以被罗氏锥虫感染，但尚未针对冈比亚锥虫（T. gambiense）描述这种模型。在这项研究中，我们报告了人类非洲锥虫病这种模型的发展。感染了冈比亚山毛榉的十二只长尾猴发展成慢性病。在五只未经治疗的动物中，疾病的持续时间在23至612天（中位数89天）之间。在感染后的前10天内在血液中和脑脊液中检测到锥虫，中位延迟为120天（n = 4，范围为28-348天）。临床变化包括体重减轻，腺病，以及在某些情况下眼睑浮肿和嗜睡。血液学改变包括血红蛋白水平降低和血小板计数短暂降低。生物修饰包括γ球蛋白和总蛋白增加以及白蛋白减少。感染的病理特征是脑实质中存在Mott细胞，单核细胞或淋巴细胞和浆细胞的炎性浸润以及星形胶质细胞增多症。这些观察结果表明，黑长尾猴中该病的发展与人类甘博氏螺旋体感染相似。我们得出结论，C。aethiops是有希望的实验灵长类动物模型，用于研究冈比亚锥虫锥虫病。

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