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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Pyomyositis in the upper Negro river basin, Brazilian Amazonia
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Pyomyositis in the upper Negro river basin, Brazilian Amazonia

机译：巴西亚马逊河黑人河上游地区的脓性肌炎

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摘要

Pyomyositis remains poorly documented in tropical Latin America. We therefore performed a retrospective review of cases admitted to a hospital in the upper Negro river basin during 2002-2006. Seasonality was assessed by the cosinor model and independent predictors of outcome were identified by logistic regression. Determinants of time-to-fever resolution were analysed using Cox regression. No seasonal trend was observed (p=0.284) among 82 hospitalised patients. The disease predominated in young males and the most commonly affected part of the body was the lower limb (68 [63.5%] out of 107 lesions). . Staphylococcus aureus was the only identified infecting organism (18 of 20 culture results, 90%). Complications occurred in 17 patients (20.7%) and the case fatality rate was 2.4%. Children were more likely to present with eosinophilia than adults (OR= 4.20, 95% CI 1.08-16.32, p=0.048), but no other significant differences regarding clinical presentation and outcomes were observed. The time-to-fever resolution was the only independent determinant of poor outcome (OR=1.52, 95% CI 1.22-1.92, p<0.001) and was significantly longer in patients treated with combined antibiotic therapy than in those treated with single antibiotics (HR=0.523, 95% CI 0.296-0.926, p=0.026). Further studies to determine the best antibiotic therapy modality for the treatment of pyomyositis are required.
机译：脓性肌炎在热带拉丁美洲尚缺乏文献报道。因此，我们对2002-2006年内格罗河上游流域的一家医院收治的病例进行了回顾性研究。通过余弦模型评估季节性，通过逻辑回归确定结果的独立预测因子。使用Cox回归分析发烧时间的决定因素。在82例住院患者中未观察到季节性趋势（p = 0.284）。该疾病主要发生在年轻男性中，身体最常见的部位是下肢（107个病变中有68个[63.5％]）。 。金黄色葡萄球菌是唯一鉴定出的感染生物（20种培养结果中的18种，占90％）。 17例患者发生并发症（20.7％），病死率为2.4％。儿童比成人更容易出现嗜酸性粒细胞增多（OR = 4.20，95％CI 1.08-16.32，p = 0.048），但是在临床表现和预后方面没有观察到其他显着差异。发热时间是不良预后的唯一独立决定因素（OR = 1.52，95％CI 1.22-1.92，p <0.001），并且联合抗生素治疗的患者明显长于单一抗生素治疗的患者（ HR = 0.523，95％CI 0.296-0.926，p = 0.026）。需要进一步的研究来确定治疗脓性肌炎的最佳抗生素治疗方法。

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