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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Differential acquisition of human antibody responses to Plasmodium falciparum according to intensity of exposure to Anopheles bites
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Differential acquisition of human antibody responses to Plasmodium falciparum according to intensity of exposure to Anopheles bites

机译：根据暴露于按蚊叮咬的强度来差异获取人对恶性疟原虫的抗体反应

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摘要

Malaria immunity is modulated by many environmental and epidemiological factors. This study evaluates the influence of a hitherto unstudied environmental-epidemiological factor, namely the impact of human exposure to Anopheles bites on the isotype profile of acquired antibody responses to Plasmodium falciparum. In two Senegalese villages where the intensity of exposure to Anopheles bites was markedly different (high and low exposure), specific IgG1 and IgG3 responses to P. falciparum whole schizont extract (WSE) and circumsporozoite protein (CSP) were evaluated at the peak of Anopheles exposure (September) and later (December) in a cohort of 120 children aged 3-8 years. Multivariate analysis showed a significantly lower IgG1 response against P. falciparum WSE and CSP in children highly exposed to Anopheles bites (Gankette) compared to those who were weakly exposed (Mboula). In contrast, in both villages, parasitemia and increasing age were strongly associated with higher IgG1 and IgG3 levels. We hypothesize that high exposure to Anopheles bites could inhibit IgG1-dependent responsiveness to P. falciparum known to induce protective immune responses against malaria. The impact of mosquito saliva on the regulation of specific protective immunity may need to be taken into account in epidemiological studies and trials for malaria vaccines.
机译：疟疾免疫力受许多环境和流行病学因素的调节。这项研究评估了迄今尚未研究的环境流行病学因素的影响，即人类暴露于按蚊叮咬对获得性针对恶性疟原虫抗体反应的同种型的影响。在两个塞内加尔村庄中，按蚊叮咬的暴露强度明显不同（高和低暴露），在按蚊高峰期评估了对恶性疟原虫全裂殖体提取物（WSE）和环子孢子蛋白（CSP）的特异性IgG1和IgG3反应。在120名3至8岁的儿童队列中（9月）和之后（12月）进行暴露。多变量分析显示，与轻度暴露者（Mboula）相比，高度暴露于按蚊叮咬（Gankette）的儿童对恶性疟原虫WSE和CSP的IgG1反应显着降低。相反，在这两个村庄中，寄生虫血症和年龄增长与IgG1和IgG3含量较高密切相关。我们假设高暴露于按蚊叮咬可以抑制对恶性疟原虫的IgG1依赖性应答，该恶性疟原虫可诱导针对疟疾的保护性免疫应答。在疟疾疫苗的流行病学研究和试验中，可能需要考虑蚊唾液对特定保护性免疫调节的影响。

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