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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Meglumine antimonate treatment enhances phagocytosis and TNF-α production by monocytes in human cutaneous leishmaniasis
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Meglumine antimonate treatment enhances phagocytosis and TNF-α production by monocytes in human cutaneous leishmaniasis

机译：葡甲胺盐酸盐治疗可增强人皮肤利什曼病中单核细胞的吞噬作用和TNF-α的产生

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摘要

This work evaluated phagocytic function, hydrogen peroxide (H 2O 2), TNF-α and IL-10 production by monocytes and serum INF-γ levels in New World human cutaneous leishmaniasis and the influence of meglumine antimonate treatment on these immune functions. The phagocytic capacity of monocytes in untreated Leishmania-infected individuals was significantly (2.5 times) lower than that of healthy controls, and antimonial treatment increased the phagocytosis by monocytes by about five times at the end of therapy. The leishmaniasis patients showed 3.9 times higher H 2O 2 production than controls and treatment with meglumine antimonate did not influence the production of H 2O 2, which remained enhanced until the end of treatment. Individuals with leishmaniasis showed 6.3 times lower TNF-α production than healthy individuals and meglumine antimonate treatment caused a significant increment (11.9 times) in its production. INF-γ serum levels were higher in Leishmania-infected individuals than healthy controls, and the production of IL-10 by monocytes was not influenced by infection or antimonial treatment. Enhancement of monocyte functions by the antimonial treatment suggests that the immunomodulatory effects of the drug may also play a part in the way meglumine antimonate acts against the parasite in human leishmaniasis, by directly increasing phagocytosis and TNF-α production.
机译：这项工作评估了新世界人类皮肤利什曼病中的吞噬功能，过氧化氢（H 2O 2），单核细胞产生的TNF-α和IL-10以及血清INF-γ水平，以及葡甲胺盐酸盐治疗对这些免疫功能的影响。未治疗的利什曼原虫感染个体中单核细胞的吞噬能力显着低于健康对照组（2.5倍），锑治疗在治疗结束时使单核细胞的吞噬作用增加了约5倍。利什曼病患者的H 2O 2产生量比对照组高3.9倍，而葡糖胺锑酸盐治疗并不影响H 2O 2的产生，直到治疗结束，H 2O 2仍会增强。利什曼病患者的TNF-α产生量比健康人低6.3倍，葡甲胺锑酸盐治疗导致其产生量显着增加（11.9倍）。利什曼原虫感染个体的INF-γ血清水平高于健康对照组，单核细胞产生的IL-10不受感染或锑治疗的影响。通过锑治疗增强单核细胞功能表明，该药物的免疫调节作用还可以通过直接增加吞噬作用和TNF-α的产生，在葡甲胺锑酸盐对人类利什曼病的寄生虫起作用的过程中发挥作用。

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