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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Risk factors for hepatitis C virus infection among Egyptian healthcare workers in a national liver diseases referral centre
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Risk factors for hepatitis C virus infection among Egyptian healthcare workers in a national liver diseases referral centre

机译：埃及国家肝脏疾病转诊中心医护人员中丙型肝炎病毒感染的危险因素

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摘要

Little is known about the prevalence of hepatitis C virus (HCV) among healthcare workers (HCW) in Egypt, where the highest worldwide prevalence of HCV exists. The prevalence of HCV, hepatitis B virus and Schistosoma mansoni antibodies was examined in 842 HCWs at the National Liver Institute in the Nile Delta, where >85% of patients are HCV antibody-positive. The mean age of HCWs was 31.5 years and they reported an average of 0.6 ± 1.2 needlesticks/HCW/year. The prevalence of anti-HCV, hepatitis B surface antigen (HBsAg) and co-infection was 16.6%, 1.5% and 0.2%, respectively. HCV-RNA was present in 72.1% of anti-HCV-positive HCWs, and all but one subject were infected with HCV genotype 4. Schistosoma mansoni antibodies were present in 35.1%. The anti-HCV rate increased sharply with age and employment duration, but not among those with needlestick history. After adjusting for other risk factors, the anti-HCV rate was higher among older HCWs [P< 0.001; risk ratio (RR) = 1.086, 95% CI 1.063-1.11], males (P= 0.002; RR = 1.911, 95% CI 1.266-2.885) and those with rural residence (P< 0.001; RR = 2.876, 95% CI 1.830-4.52). Occupation (P= 0.133), duration of employment (P= 0.272) or schistosomal antibody positivity (P= 0.152) were not significant risk factors for anti-HCV positivity. In conclusion, although one in six HCWs had been infected with HCV, the infections were more likely to be community-acquired and not occupationally related.
机译：对于埃及的医护人员（HCW）中的丙型肝炎病毒（HCV）患病率知之甚少，埃及是全世界HCV患病率最高的国家。在尼罗河三角洲国家肝脏研究所的842名HCW中检查了HCV，乙型肝炎病毒和曼氏血吸虫抗体的患病率，其中超过85％的患者HCV抗体阳性。 HCW的平均年龄为31.5岁，他们报告的平均针刺数/ HCW /年为0.6±1.2。抗HCV，乙肝表面抗原（HBsAg）和合并感染的患病率分别为16.6％，1.5％和0.2％。 HCV-RNA出现在72.1％的抗HCV阳性HCW中，除一名受试者外，其他所有人均感染了HCV基因型4。曼氏血吸虫抗体的出现率为35.1％。抗HCV率随年龄和就业时间的增加而急剧增加，但在有针刺病史的患者中却没有。调整其他风险因素后，老年HCW中的抗HCV率较高[P <0.001;风险比（RR）= 1.086，95％CI 1.063-1.11]，男性（P = 0.002; RR = 1.911，95％CI 1.266-2.885）和有农村居民的人群（P <0.001; RR = 2.876，95％CI 1.830-4.52）。职业（P = 0.133），就业时间（P = 0.272）或血吸虫抗体阳性（P = 0.152）不是抗HCV阳性的重要危险因素。总之，尽管六分之一的医护人员感染了丙型肝炎病毒，但这种感染更有可能是社区获得的，与职业无关。

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