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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Histoplasmosis in HIV-positive patients in Ceará, Brazil: Clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolates
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Histoplasmosis in HIV-positive patients in Ceará, Brazil: Clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolates

机译：巴西塞阿拉州HIV阳性患者的组织胞浆菌病：荚膜组织胞浆菌分离物的临床实验室方面和体外抗真菌药性

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摘要

This study contains a descriptive analysis of histoplasmosis in AIDS patients between 2006 and 2010 in the state of Ceará, Brazil. Additionally, the in vitro susceptibility of Histoplasma capsulatum isolates obtained during this period was assessed. We report 208 cases of patients with histoplasmosis and AIDS, describing the epidemiological, clinical, laboratory and therapeutic aspects. The in vitro antifungal susceptibility test was carried out by the microdilution method, according to Clinical and Laboratory Standards Institute, with H. capsulatum in the filamentous and yeast phases, against the antifungals amphotericin B, fluconazole, itraconazole, voriconazole and caspofungin. In 38.9% of the cases, histoplasmosis was the first indicator of AIDS and in 85.8% of the patients the CD4 cell count was lower than 100 cells/mm 3. The lactate dehydrogenase levels were high in all the patients evaluated, with impairment of hepatic and renal function and evolution to death in 42.3% of the cases. The in vitro susceptibility profile demonstrated there was no antifungal resistance among the isolates evaluated. There was a significant increase in the number of histoplasmosis cases in HIV-positive patients during the period surveyed in the state of Ceará, northeastern Brazil, but no antifungal resistance among the recovered isolates of H. capsulatum.
机译：这项研究包含2006年至2010年之间巴西塞阿拉州的艾滋病患者组织胞浆病的描述性分析。另外，评估了在此期间获得的荚膜组织胞浆菌分离物的体外敏感性。我们报告208例组织胞浆菌病和艾滋病患者，描述了流行病学，临床，实验室和治疗方面。根据临床和实验室标准协会，通过微稀释法，在荚膜H.荚膜菌丝状和酵母菌阶段，通过微稀释法对抗真菌药两性霉素B，氟康唑，伊曲康唑，伏立康唑和卡泊芬净进行了体外抗真菌药敏试验。在38.9％的病例中，组织胞浆菌病是AIDS的第一指征，在85.8％的患者中，CD4细胞计数低于100细胞/ mm 3。在所有评估的患者中，乳酸脱氢酶水平较高，伴有肝功能损害肾功能和演变为死亡的占42.3％。体外药敏曲线表明，在评估的分离物中没有抗真菌抗药性。在巴西东北部塞阿拉州进行调查的期间，HIV阳性患者的组织胞浆菌病病例数显着增加，但是在回收的荚膜嗜血杆菌分离株中没有抗真菌耐药性。

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