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Blood group phenotypes A and B are risk factors for cerebral malaria in Odisha, India

机译:血型A和B型是印度奥里萨邦脑疟的危险因素

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There is increasing evidence that the ABO blood group phenotypes modulates . Plasmodium falciparum rosetting and may influence the clinical manifestation of severe malaria. Whether blood group phenotypes are associated with risk of severe . falciparum malaria in Odisha, we analyzed 343 adult malaria patients. The results showed high prevalence of blood group B in both mild (n. =. 110) and severe malaria (cerebral malaria [CM]; n. =. 130 and non-cerebral severe malaria [NCSM]; n. =. 103) categories among the non-O group and while type O is significantly associated with protection against CM, patients with type A and B group had increased risk for developing CM. Further, the strength of association for B group (p. =. < 0.0001) was high and has double the risk of (OR. =. 5.0) of developing CM compared to blood group A (OR. =. 2.5). Such findings may probably be due to strain specific blood group preferences of . P. falciparum and high prevalence of B group. However, the ABO blood group distribution of mild malaria was comparable with that of the NCSM group of patients. The lack of association of ABO phenotypes with NCSM is evidence for the hypothesis that the underlying pathogenesis cascades are different in CM and NCSM clinical presentations.
机译:越来越多的证据表明ABO血型可以调节表型。恶性疟原虫玫瑰花结并可能影响严重疟疾的临床表现。血型表型是否与发生严重肝癌的风险有关。奥里萨邦的恶性疟疾,我们分析了343名成人疟疾患者。结果显示,在轻度(n。= 110)和严重疟疾(脑性疟疾[CM]; n。=。130和非脑性严重疟疾[NCSM]; n。=。103)中,血型B的患病率均很高。非O组和O型与CM的保护作用显着相关,而A和B组的患者发生CM的风险增加。此外,与血型A组相比,B组的关联强度(p。=。<0.0001)高,罹患CM的风险(OR。=。5.0)是其两倍。这样的发现可能是由于菌株特定的血型偏好。恶性疟原虫和B组患病率高。但是,轻度疟疾的ABO血型分布与NCSM组的患者相当。 ABO表型与NCSM缺乏关联,这证明了以下假设:在CM和NCSM临床表现中潜在的发病机制级联是不同的。

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