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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Comparison of the reactogenicity of three different immunization schedules including diphtheria, tetanus, pertussis, Haemophilus influenza b and polio vaccine in Turkey.
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Comparison of the reactogenicity of three different immunization schedules including diphtheria, tetanus, pertussis, Haemophilus influenza b and polio vaccine in Turkey.

机译：土耳其三种不同免疫方案（包括白喉，破伤风，百日咳，乙型流感嗜血杆菌和脊髓灰质炎疫苗）的反应原性比较。

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摘要

In Turkey, several changes have been made in the vaccination schedule. Vaccines against diphtheria, tetanus, pertussis and poliomyelitis were applied as DTwP and OPV until the end of 2006. Hib vaccine was added to the schedule and was administered as a separate injection in 2007 as DPT + OPV + Hib. DTaP-IPV/Hib combined vaccine replaced them in 2008. The aim of this study was to evaluate the alterations in the frequency of adverse reactions of these different schedules in the consecutive three years.A total of 2401 infants who were vaccinated in Gazi University Well Child Clinics during the first 3 months of each schedule were enrolled in the study. Local and systemic adverse events were recorded in diaries by the parents for the next three days.No significant differences existed between infants vaccinated with DPT + OPV and DPT + OPV + Hib regarding all adverse events detected. Frequency of local and systemic reactions were lower in infants vaccinated with DTaP-IPV/Hib combined vaccine (p < 0.001). Frequency of adverse events in infants vaccinated with DPT + OPV or DPT+ OPV + Hib were highest at booster doses.The original experience of the study is the demonstration of the adverse event profile for three different schedules which allowed us to draw the profile of the adverse events in a country with changing national schedules. Implementation of Schedule 3 reduced the adverse events of vaccination. Thus reduction in the number of injections and reactogenicity of pertussis vaccine contributed to an increase in the compliance to the vaccination program.
机译：在土耳其，疫苗接种时间表已作了几处更改。抗白喉，破伤风，百日咳和小儿麻痹症的疫苗已被用作DTwP和OPV，直到2006年底。Hib疫苗已列入时间表，并于2007年作为DPT + OPV + Hib单独注射。 DTaP-IPV / Hib联合疫苗在2008年替代了它们。本研究的目的是评估连续三年中这些不同时间表的不良反应发生率的变化。加济大学医学院共有2401例婴儿接受了疫苗接种在每个时间表的前三个月内的儿童诊所都参加了这项研究。父母在随后三天的日记中记录了局部和全身性不良事件。接种DPT + OPV和DPT + OPV + Hib的婴儿在所有不良事件方面均无显着差异。接种DTaP-IPV / Hib联合疫苗的婴儿的局部和全身反应的频率较低（p <0.001）。接种DPT + OPV或DPT + OPV + Hib疫苗的婴儿发生不良事件的频率在加强剂量时最高。该研究的原始经验是证明了三种不同时间表的不良事件概况，这使我们能够得出不良反应的概况。更改国家时间表的国家发生的事件。实施附表3减少了疫苗接种的不良事件。因此，百日咳疫苗的注射数量和反应原性的减少有助于增加对疫苗接种计划的依从性。

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