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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Evaluation of compliance to congenital Chagas disease treatment: results of a randomised trial in Bolivia.
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Evaluation of compliance to congenital Chagas disease treatment: results of a randomised trial in Bolivia.

机译：先天性恰加斯病治疗依从性评估：玻利维亚的一项随机试验结果。

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摘要

A randomised, unblinded, clinical trial comparing two benznidazole regimens for congenital Chagas disease was carried out to determine whether simplification and reduction in the length of treatment could lead to better treatment compliance.This study was conducted in Santa Cruz, Bolivia. Serological screening was carried out in pregnant women, and parasites were sought in the blood of newborns from seropositive mothers. Infected infants were randomly assigned to two treatment groups. Recovery was assessed by parasite seeking at 1 month and 2 months as well as serological tests at 9 months. Assessment of treatment adherence was based on weekly home visits and use of electronic monitors.Benznidazole was given to 63 newborns in group A (5 mg/kg in two daily doses for 60 days) and 61 newborns in group B (7.5 mg/kg in a single daily dose for 30 days). There was no difference in compliance between the two groups. The study confirmed the efficacy and good tolerance of both benznidazole regimens in the treatment of congenital Chagas disease.The short treatment should be preferred as it allows reducing the dose of benznidazole as well as the cost of treatment.
机译：在玻利维亚圣克鲁斯进行了一项随机，无盲的临床试验，该试验比较了两种苯硝唑对先天性恰加斯病的治疗方案，以确定简化和缩短治疗时间是否可以导致更好的治疗依从性。对孕妇进行了血清学筛查，并在血清阳性母亲的新生儿血液中寻找了寄生虫。被感染的婴儿被随机分为两个治疗组。通过在1个月和2个月进行寄生虫搜寻以及在9个月进行血清学检测来评估恢复情况。对治疗依从性的评估基于每周的家庭访视和使用电子监护仪进行的评估.A组中的63例新生儿（5毫克/千克，每天两次，共60天）被给予苯乙唑。 30天的单日剂量）。两组之间的依从性没有差异。该研究证实了两种苯并咪唑方案在治疗先天性恰加斯病中的疗效和良好的耐受性，因此应首选短期治疗，因为它可以减少苯并硝唑的剂量以及治疗费用。

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