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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Serum iron profile and ELISA-based detection of antibodies against the iron-regulated protein HupB of Mycobacterium tuberculosis in TB patients and household contacts in Hyderabad (Andhra Pradesh), India.
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Serum iron profile and ELISA-based detection of antibodies against the iron-regulated protein HupB of Mycobacterium tuberculosis in TB patients and household contacts in Hyderabad (Andhra Pradesh), India.

机译：印度海得拉巴（Andhra Pradesh）结核病患者和家庭接触者的血清铁谱和基于ELISA的抗结核分枝杆菌结核分枝杆菌HupB的抗体检测。

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摘要

HupB is a 28 kDa cell-wall-associated protein co-expressed with the siderophores mycobactin and carboxymycobactin in iron-limited Mycobacterium tuberculosis. HupB is expressed in vivo and anti-HupB antibodies are present in the serum of TB patients.The aims of this study were to evaluate the serodiagnostic potential of HupB and to correlate levels of anti-HupB antibodies with the serum iron status in TB patients, household contacts and normal healthy controls.TB patients from Hyderabad (India) showed high levels of anti-HupB antibodies compared with household contacts and normal healthy controls. Interestingly, the levels were maximal in extrapulmonary TB patients, with a two-fold higher titre than pulmonary TB patients. Serum iron levels, total iron-binding capacity (TIBC) and percent saturation of serum transferrin were low in subjects with active TB, whilst serum ferritin was notably high in pulmonary TB patients compared with normal controls.There is a strong negative correlation between serum iron levels and TIBC with the titre of anti-HupB antibodies in subjects with active TB. This study reflects the usefulness of screening for anti-HupB antibodies for diagnosis of pulmonary and extrapulmonary TB in this endemic region.
机译：HupB是在铁受限的结核分枝杆菌中与铁载体霉菌素和羧基霉菌素共表达的28 kDa细胞壁相关蛋白。 HupB在体内表达且抗HupB抗体存在于结核病患者的血清中。本研究的目的是评估HupB的血清诊断潜力，并将抗HupB抗体的水平与结核病患者的血清铁水平相关联，家庭接触者和正常健康对照：与家庭接触者和正常健康对照相比，来自印度海得拉巴的结核病患者显示出高水平的抗HupB抗体。有趣的是，肺外结核病患者的水平最高，其滴度是肺结核病患者的两倍。活动性结核病患者的血清铁水平，总铁结合能力（TIBC）和血清转铁蛋白饱和度较低，而肺结核患者的血清铁蛋白显着高于正常对照组。血清铁之间存在很强的负相关性活动性结核病患者的抗HupB抗体滴度和TIBC水平和TIBC的滴度。这项研究反映了筛查抗HupB抗体对诊断该地区流行的肺结核和肺外结核的有用性。

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