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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels.
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Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels.

机译：合并感染HTLV-1和stericalalis stercoralis的患者的圆线虫病与TNFα升高和可溶性IL2受体水平降低有关。

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摘要

Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL).We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection.Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis.These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.
机译：人类T细胞淋巴病毒1型（HTLV-1）感染与复发性和弥散性圆线虫病和成人T细胞白血病/淋巴瘤（ATLL）有关。并评估了强固龙虾治疗对HTLV-1感染的免疫反应和临床结局的影响。HTLV-1和S.stercoralis并发患者的TNFα和IFNγ水平低于仅HTLV-1的患者（p < 0.05），并且驱虫治疗后TNFα水平升高。 HTLV-1合并固醇链球菌感染的患者中sIL-2R的水平较高，而驱虫药使sIL-2R的水平降低（p <0.05）。一名发展为ATLL的患者与stercoralis共感染，这些数据表明蠕虫感染在HTLV-1感染中起调节作用，而sterellaalis可能是ATLL发生的辅助因素。

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