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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Gene diversity and genetic variation in lung flukes (genus Paragonimus)
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Gene diversity and genetic variation in lung flukes (genus Paragonimus)

机译：肺吸虫（Paragonimus属）的基因多样性和遗传变异

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摘要

Paragonimiasis caused by lung flukes (genus Paragonimus) is a neglected disease occurring in Asia, Africa and the Americas. The genus is species-rich, ancient and widespread. Genetic diversity is likely to be considerable, but investigation of this remains confined to a few populations of a few species. In recent years, studies of genetic diversity have moved from isoenzyme analysis to molecular phylogenetic analysis based on selected DNA sequences. The former offered better resolution of questions relating to allelic diversity and gene flow, whereas the latter is more suitable for questions relating to molecular taxonomy and phylogeny. A picture is emerging of a highly diverse taxon of parasites, with the greatest diversity found in eastern and southern Asia where ongoing speciation might be indicated by the presence of several species complexes. Diversity of lung flukes in Africa and the Americas is very poorly sampled. Functional molecules that might be of value for immunodiagnosis, or as targets for medical intervention, are of great interest. Characterisation of these from Paragonimus species has been ongoing for a number of years. However, the imminent release of genomic and transcriptomic data for several species of Paragonimus will dramatically increase the rate of discovery of such molecules, and illuminate their diversity within and between species.
机译：肺吸虫（肺吸虫属）引起的肺吸虫病是一种在亚洲，非洲和美洲发生的被忽视的疾病。该属物种丰富，古老且分布广泛。遗传多样性可能相当可观，但是对此的研究仍局限于少数物种的少数种群。近年来，基于选定的DNA序列，遗传多样性的研究已从同工酶分析转向分子系统发育分析。前者可以更好地解决与等位基因多样性和基因流有关的问题，而后者更适合于与分子分类学和系统发育有关的问题。出现了一个高度多样化的寄生生物分类图，在东亚和南亚发现了最大的多样性，那里存在着几种物种复合体，这表明正在进行物种的形成。在非洲和美洲，肺吸虫的多样性非常少。可能对免疫诊断有价值或作为医学干预目标的功能分子引起了极大的兴趣。多年以来，对来自Paragonimus物种的这些细菌进行鉴定一直在进行中。然而，即将发布的几种对agon虫的基因组和转录组数据将大大增加发现此类分子的速度，并阐明它们在种内和种间的多样性。

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