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首页> 外文期刊>Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems >Mechanisms and genes involved in enhancement of HIV infectivity by tobacco smoke.
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Mechanisms and genes involved in enhancement of HIV infectivity by tobacco smoke.

机译：烟草烟雾增强HIV感染力的机制和基因。

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摘要

HIV infection is more common among smokers than nonsmokers, and, remarkably, HIV-infected individuals are about 3 times more likely to smoke than the uninfected general population. However, the relationship between tobacco smoking and HIV/AIDS disease progression remains controversial. In this study, we demonstrate a potent enhancing effect of aqueous tobacco smoke extract (TSE) on HIV infectivity that is nicotine-independent. This increased infectivity is neither NF-kappaB mediated nor a direct result of oxidative stress, as it cannot be blocked by antioxidants. On the contrary, TSE itself was found to possess significant antioxidant potential, enabling it to protect the viability of both infected cells and HIV virions in the presence of peroxide. Assessment of TSE-induced alterations in cellular gene expression that may be involved in increasing HIV infectivity in T cells showed that TSE up-regulates some genes known to be capable of enhancing HIV and HCV infection, or protecting HIV, but down-regulates several genes involved in cellular defense and antigen presentation. These results demonstrate that tobacco smoke can enhance HIV infectivity, possibly by a combination of direct (antioxidant) and indirect (gene-based) mechanisms. This raises the concern that smoking may thereby increase the risk of acquisition or progression of HIV infection.
机译：在吸烟者中，HIV感染比不吸烟者更为普遍，而且值得注意的是，感染HIV的个体吸烟的可能性是未感染普通人群的约3倍。但是，吸烟与艾滋病毒/艾滋病疾病进展之间的关系仍然存在争议。在这项研究中，我们证明了烟熏水提取物（TSE）对不依赖尼古丁的HIV感染力的有效增强作用。这种增加的传染性既不是NF-κB介导的，也不是氧化应激的直接结果，因为它不能被抗氧化剂阻止。相反，发现TSE本身具有强大的抗氧化潜能，使其能够在过氧化物存在的情况下保护感染细胞和HIV病毒粒子的生存能力。 TSE诱导的细胞基因表达变化可能与T细胞中HIV感染性增加有关，评估表明TSE上调一些已知能够增强HIV和HCV感染或保护HIV的基因，但下调了一些基因参与细胞防御和抗原呈递。这些结果表明，烟草烟雾可以通过直接（抗氧化剂）和间接（基于基因）机制的结合来增强HIV的感染力。这引起了人们的担忧，即吸烟可能会增加艾滋病毒感染的发生或发展的风险。

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