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首页> 外文期刊>Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems >Minocycline increases the life span and motor activity and decreases lipid peroxidation in manganese treated Drosophila melanogaster
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Minocycline increases the life span and motor activity and decreases lipid peroxidation in manganese treated Drosophila melanogaster

机译：米诺环素可延长锰治疗的果蝇的寿命，并降低其运动能力，并降低脂质过氧化作用

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摘要

The objective of this study was to investigate the effect of Minocycline in the life span, motor activity, and lipid peroxidation of Drosophila melanogaster treated with manganese. Two days after emerging from the pupa male wild-type D. melanogaster were fed for 13 days with corn media containing 15. mM manganese. Then, they were divided in six groups of 300 flies each: group (a) remained treated with manganese (Mn group); group (b) began treatment with Minocycline (0.05. mM) (Mn. - Minocycline group); group (c) received no additional treatment (Mn-no treatment group); group (d) simultaneously fed with manganese and Minocycline (Mn. +. Minocycline group). Additionally, a control (group e) with no treatment and another group (f) fed only with Minocycline after emerging from the pupa were added. All the manganese treated flies (group a) were dead on the 25th day. The life span in group f (101.66 ± 1.33 days, mean S.E.M.) and of group b (97.00 ± 3.46 days) were similar, but in both cases it was significantly higher than in group e (68.33 ± 1.76 days), group c (67.05 ± 2.30 days) and in those of group d (37.33 ± 0.88). Manganese (groups a and d) decreased motor activity in D. melanogaster. In the Minocycline fed flies (groups b and f) a higher motor activity was detected. In Mn. - Minocycline and Mn. +. Minocycline treated flies a significant decrease of MDA levels was detected when compared to the Minocycline group indicating that Minocycline and Mn appear to have a synergistic effect. In conclusion, Minocycline increased the life span and motor activity and decreased MDA formation of manganese treated D. melanogaster, probably by an inhibition of the production of reactive oxygen species. Manganese also exerted an antioxidant effect as shown by the significant decrease of MDA levels when compared to control flies.
机译：这项研究的目的是研究米诺环素对锰处理过的果蝇的寿命，运动活动和脂质过氧化的影响。从the中取出后的两天，用含有15 mM锰的玉米培养基喂养雄性野生D. melanogaster达13天。然后，将它们分为六组，每组300只苍蝇：（a）组继续用锰处理（Mn组）; （b）组开始用米诺环素（0.05。mM）治疗（锰-米诺环素组）; （c）组未接受其他治疗（Mn-无治疗组）; （d）组同时饲喂锰和米诺环素（Mn。+。米诺环素组）。另外，加入未处理的对照组（e组）和仅从Min中出来后仅喂食米诺环素的另一组（f）。所有经过锰处理的果蝇（a组）在第25天死亡。 f组（101.66±1.33天，平均SEM）的寿命与b组（97.00±3.46天）的寿命相似，但在两种情况下，其寿命均显着高于c组的e组（68.33±1.76天）。 67.05±2.30天）和d组（37.33±0.88）。锰（a和d组）降低了D. melanogaster的运动活动。在米诺环素喂养的果蝇（b和f组）中，检测到较高的运动活动。在锰中。 -米诺环素和锰。 +。与米诺环素组相比，经米诺环素处理的果蝇的MDA水平显着降低，表明米诺环素和Mn似乎具有协同作用。总之，米诺环素可能通过抑制活性氧的产生而延长了锰处理过的黑腹果蝇的寿命和运动活性，并减少了MDA的形成。锰还发挥了抗氧化作用，与对照果蝇相比，丙二醛水平显着降低。

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