CHARACTERIZATION OF MOCARHAGIN, A COBRA VENOM METALLOPROTEINASE FROM NAJA MOCAMBIQUE MOCAMBIQUE, AND RELATED PROTEINS FROM OTHER ELAPIDAE VENOMS

Ward CM.; Andrews RK.; Berndt MC.; Vinogradov DV.

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CHARACTERIZATION OF MOCARHAGIN, A COBRA VENOM METALLOPROTEINASE FROM NAJA MOCAMBIQUE MOCAMBIQUE, AND RELATED PROTEINS FROM OTHER ELAPIDAE VENOMS

机译：眼镜蛇毒，眼镜蛇毒金属蛋白酶（眼镜蛇毒金属蛋白酶）的特征以及其他蛇毒的相关蛋白的表征

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Mocarhagin, a cobra venom metalloproteinase from Naja mocambique mocambique, has previously been shown to cleave selectively two mucin-like substrates on platelets and neutrophils within anionic amino acid sequences containing sulfated tyrosines, We now show that purified mocarhagin has haemagglutinin activity, and a similar profile for inhibition of mocarhagin-dependent haemagglutination and proteolysis suggests that the lectin-like domain may account for its substrate specificity, In addition, immunologically and functionally related proteins were detected in other Elapidae venoms. Copyright (C) 1996 Elsevier Science Ltd [References: 10]

机译：Mocarhagin，一种来自眼镜蛇眼镜蛇毒液的眼镜蛇毒金属蛋白酶，以前已被证明可以在含硫酸化酪氨酸的阴离子氨基酸序列中选择性地裂解血小板和嗜中性粒细胞上的两种粘蛋白样底物，我们现在表明纯化的Mocarhagin具有血凝素活性，并且具有相似的特征抑制mocarhagin依赖的血凝和蛋白水解的研究表明，凝集素样结构域可能是其底物特异性的原因。此外，在其他天疱疮毒液中还检测到了与免疫和功能相关的蛋白质。版权所有（C）1996 Elsevier Science Ltd [参考：10]

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《Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms》 |1996年第10期|共4页
作者
Ward CM.; Andrews RK.; Berndt MC.; Vinogradov DV.;
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正文语种 eng
中图分类药学;毒物学（毒理学）;
关键词
Snake-venoms; Binding; Lectins;

机译：蛇毒;结合;凝集素;

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1. CHARACTERIZATION OF MOCARHAGIN, A COBRA VENOM METALLOPROTEINASE FROM NAJA MOCAMBIQUE MOCAMBIQUE, AND RELATED PROTEINS FROM OTHER ELAPIDAE VENOMS [J] . Ward CM., Andrews RK., Berndt MC., Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 1996,第10期

机译：眼镜蛇毒，眼镜蛇毒金属蛋白酶（眼镜蛇毒金属蛋白酶）的特征以及其他蛇毒的相关蛋白的表征
2. MOCARHAGIN, A NOVEL COBRA VENOM METALLOPROTEINASE, CLEAVES THE PLATELET VON WILLEBRAND FACTOR RECEPTOR GLYCOPROTEIN IB-ALPHA - IDENTIFICATION OF THE SULFATED TYROSINE/ANIONIC SEQUENCE TYR-276-GLU-282 OF GLYCOPROTEIN IB-ALPHA AS A BINDING SITE FOR VON [J] . Ward CM, Andrews RK, Smith AI, Biochemistry . 1996,第15期

机译：MOCARHAGIN是一种新型眼镜蛇毒金属蛋白酶，可清除血小板冯·威勒伯兰因子受体糖蛋白IB-Alpha-硫酸酪氨酸/阴离子序列的鉴定TYR-276-GLU-282糖蛋白聚糖的抗原肽
3. Fractionation of snake venom metalloproteinases by metal ion affinity: A purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose [J] . Wijeyewickrema LC, Gardiner EE, Shen Y, Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2007,第8期

机译：通过金属离子亲和力分离蛇毒金属蛋白酶：来自眼镜蛇的纯化眼镜蛇金属蛋白酶Nk与Ni2 +-琼脂糖结合
4. ECG delineation techniques and applications in Cobra venom interacted patients [C] . Maheshwari R., Kumar V., Verma H.K. . 2009

机译：心电图描绘技术及其在眼镜蛇毒相互作用患者中的应用
5. Functional characterization of human glycoprotein Ib (GPIb) in platelets and endothelial cells using viper venom proteins. [D] . Tan, Li. 1998

机译：使用毒蛇毒蛋白在血小板和内皮细胞中人糖蛋白Ib（GPIb）的功能表征。
6. Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae) [O] . J.M. Conlon, Samir Attoub, Vishal Musale, 2020

机译：黑颈随地吐痰眼镜蛇眼镜蛇眼镜蛇（蛇蝎）毒液的细胞毒性和胰岛素释放成分的分离与表征
7. Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae) [O] . J.M. Conlon, Samir Attoub, Vishal Musale, 2020

机译：从黑颈吐痰Cobra Nigricolis（Elapidae）的毒液中细胞毒性和胰岛素释放组分的分离与表征
8. Dose -Response Relationship of Crude COBRA Venom (Naja Jana) in the Dog [R] . Ciuchta, H. P., Vick, J. A., Manthei, J. H. 1967

机译：剂量 - 响应原油COBRa毒液（Naja Jana）在狗中的关系

CHARACTERIZATION OF MOCARHAGIN, A COBRA VENOM METALLOPROTEINASE FROM NAJA MOCAMBIQUE MOCAMBIQUE, AND RELATED PROTEINS FROM OTHER ELAPIDAE VENOMS

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