Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected.

Whittington CM; Papenfuss AT; Kuchel PW; Belov K

首页> 外文期刊>Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms >Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected.

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Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected.

机译：鸭嘴兽防御素和相关毒液基因在多种组织类型中的表达模式揭示了OvDLPs较以前怀疑的功能更广泛的可能性。

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The platypus, as an egg-laying mammal, displays an unusual mixture of reptilian and mammalian characteristics. It is also venomous, and further investigations into its little-studied venom may lead to the development of novel pharmaceuticals and drug targets and provide insights into the origins of mammalian venom. Here we investigate the expression patterns of antimicrobial genes called defensins, and also the venom peptides called defensin-like peptides (OvDLPs). We show, in the first expression study on any platypus venom gene, that the OvDLPs are expressed in a greater range of tissues than would be expected for genes with specific venom function, and thus that they may have a wider role than previously suspected.

机译：鸭嘴兽作为产卵的哺乳动物，表现出爬行动物和哺乳动物特征的不寻常混合物。它也是有毒的，对其很少研究的毒液的进一步研究可能会导致开发新的药物和药物靶标，并为了解哺乳动物毒液的起源提供见识。在这里，我们研究了称为防御素的抗菌素基因的表达模式，以及称为防御素样肽（OvDLP）的毒肽。我们在任何鸭嘴兽毒液基因的首次表达研究中表明，与具有特定毒液功能的基因相比，OvDLPs在更大范围的组织中表达，因此它们可能比以前怀疑的作用更广泛。

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《Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms》 |2008年第4期|共7页
作者
Whittington CM; Papenfuss AT; Kuchel PW; Belov K;
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正文语种 eng
中图分类药学;毒物学（毒理学）;
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1. Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected. [J] . Whittington CM, Papenfuss AT, Kuchel PW, Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2008,第4期

机译：鸭嘴兽防御素和相关毒液基因在多种组织类型中的表达模式揭示了OvDLPs较以前怀疑的功能更广泛的可能性。
2. Broad patterns of gene expression revealed hy clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays [J] . U. ALON, D. A. NOTTERMAN Proceedings of the National Academy of Sciences of the United States of America . 1999,第12期

机译：基因表达的广泛模式揭示了通过寡核苷酸阵列探测的肿瘤和正常结肠组织的聚类分析
3. Defensins and the convergent evolution of platypus and reptile venom genes. [J] . Whittington CM, Papenfuss AT, Bansal P, Genome research . 2008,第6期

机译：防御素和鸭嘴兽和爬行动物毒液基因的趋同进化。
4. Broad Patterns of Gene Expression Revealed by Clustering Analysis of Tumor and Normal Lung Tissues Probed by cDNA Microarrays [C] . Yingwu Huang International Conference on Engineering and Technological Sciences 2000 Session 8 Biochip Technologies, Oct 11, 2000, Beijing, China . 2000

机译：cDNA芯片探测的肿瘤和正常肺组织的聚类分析揭示了广泛的基因表达模式
5. Broad Complex evolution, function and expression: Insights from tissue reorganization during metamorphosis. [D] . Spokony, Rebecca Fran. 2007

机译：广泛的复杂进化，功能和表达：在变态过程中组织重组的见解。
6. Defensins and the convergent evolution of platypus and reptile venom genes [O] . Camilla M. Whittington, Anthony T. Papenfuss, Paramjit Bansal, 2008

机译：防御素与鸭嘴兽和爬行动物毒液基因的融合进化
7. : "This paper deals with the functionality of the flaked stone assemblages from several Neolithic sites of the NE of the Iberian Peninsula. The chronological framework ranges from the mid-6th to the mid-4th millennium cal. BCE, which corresponds to the Early and Middle Neolithic. This long period ranges from the arrival of the first farming communities in the Iberian Peninsula, around 5600-5500 cal. BCE, to 3600-3500 cal. BCE, two millennia later, when Neolithic communities had stably occupied most of the available territory, from the mountainous areas of the Pyrenees to the coastal areas of the Mediterranean.In this context, the NE of the Iberian Peninsula is one of the areas where a major number of use-wear analyses have been carried out, especially for what concerns the Neolithic period. This is mainly due to the interest shown by the directors of the excavations and by the Spanish use-wear specialists as well; both participated and cooperated in order to enlarge the number of contexts studied, making the NE of the Iberian Peninsula one of the areas of Europe with the largest number of ‘functional studies’. As a result, today we have a reliable picture of the type of lithic tools used by the first farming groups, how they were used, and which needs they were satisfying.The methodology employed for this type of analysis is today broadly shared by most use-wear specialists. A stereoscopic microscope is used together with a reflected-light microscope for the analysis of the archaeological specimens. Afterwards, the observed use-wear traces are compared with the traces from experimental tools. This study primarily made use of the tools preserved at the ‘Traceoteque’ of the Institución Milà y Fontanals of the CSIC of Barcelona.This paper presents the results obtained for the different types of analysed sites and the relative lithic assemblages. In this way, tools from different contexts are compared: open-air sites, caves and rock-shelters, pit-sites, burials, and mining sites. Such a diversity of contexts allowed for the exploration of the existence of recurrences and differences in the functionality of the lithic tools from one site to another. The results obtained have also provided information on some aspects related to the economic processes carried out at the different sites, caves, rock-shelters and open-air contexts. It has been possible to gain fresh data on the types of tasks carried out and their relative importance for each site, their relation with the geographical and environmental context and the natural resources available there. In addition, analysing tools recovered from burials – mainly individual inhumations – provided information on the relationships between the buried individuals and the working tools, in particular exploring the relationships between sex and age patterns and the types of tools deposited as goods.In conclusion, use-wear analysis allowed for the exploration of a variety of issues; from technical aspects related to the production and management of the lithic resources to social aspects related to the subsistence activities and the individuals that carried them out." [O] . Gibaja Bao, Juan Francisco, Mazzucco, Niccolo 2015

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Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected.

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