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Effects of alcohol before, during and after acute paraquat poisoning in rats

机译：百草枯中毒对大鼠急性酒精中毒的影响

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摘要

This study aimed to explore the effects of alcohol on paraquat dichloride (PQ) poisoning. Compared to PQ administration alone, alcohol gavage intervention before PQ administration could delay the peak time of plasma C-max. Myeloperoxidase (MPO) levels were correlated with the level of hydroxyl radical inhibiting ability. The alcohol gavage intervention led to aggravated acute lung injury by improving the inflammatory reaction and reactive oxygen generation. There was a positive correlation between oxidative stress and inflammatory reaction after acute PQ administration. Alcohol intake in combination with PQ poisoning can increase MPO levels, reduce OH- and aggravate lung tissue damage.
机译：这项研究旨在探讨酒精对百草枯二氯化物（PQ）中毒的影响。与单独进行PQ相比，在进行PQ之前进行管饲干预可能会延迟血浆C-max的峰值时间。髓过氧化物酶（MPO）水平与羟自由基抑制能力水平相关。酒精管饲干预通过改善炎症反应和活性氧生成，导致急性肺损伤加重。急性PQ给药后，氧化应激与炎症反应之间呈正相关。摄入酒精并伴有PQ中毒可增加MPO水平，降低OH-并加重肺组织损害。

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