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首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >Granulocyte colony-stimulating factor as a potential inducer of ovulation in infertile women with luteinized unruptured follicle syndrome
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Granulocyte colony-stimulating factor as a potential inducer of ovulation in infertile women with luteinized unruptured follicle syndrome

机译：黄素化未破裂卵泡综合征的不育妇女中的粒细胞集落刺激因子可能是排卵的诱因

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摘要

Luteinized unruptured follicle (LUF) syndrome is one of the intractable ovulation disorders that are commonly observed during cycles of treatment with ovulation inducers, for which no effective therapy other than assisted reproductive technology is available. Here, we investigated whether granulocyte colony-stimulating factor (G-CSF) could prevent the onset of LUF syndrome. We analyzed the effects of G-CSF in 68 infertile women with LUF syndrome who received ovulation induction (clomiphene + human chorionic gonadotropin (hCG) therapy or follicle stimulating hormone + hCG therapy). G-CSF (lenograstim, 100 Fig) was administered subcutaneously. Onsets of LUF syndrome were compared between the cycle during which G-CSF was given in combination with the ovulation inducer (ie, the G-CSF treatment cycle) and the subsequent cycle during which only the ovulation inducer was given (ie, the G-CSF nontreatment control cycle). The results showed that LUF syndrome recurred in only 3 cycles during the G-CSF treatment cycle (4.4% (3/68 cycles)), whereas LUF syndrome recurred in 13 cycles during the subsequent G-CSF nontreatment control cycle (19.1% (13/68 cycles)). The additional use of G-CSF significantly prevented the onset of LUF syndrome during ovulation induction (P = 0.013, McNemar test). No serious adverse reactions because of the administration of G-CSF were observed. In conclusion, our findings indicate that G-CSF may become a useful therapy for LUF syndrome.
机译：黄体化未破裂卵泡（LUF）综合征是难治性排卵疾病之一，通常在用排卵诱导剂治疗的周期中观察到，对于这些疾病，除辅助生殖技术外，没有其他有效的治疗方法。在这里，我们调查了粒细胞集落刺激因子（G-CSF）是否可以预防LUF综合征的发作。我们分析了G-CSF在68名接受排卵诱导（氯米芬+人绒毛膜促性腺激素（hCG）治疗或卵泡刺激素+ hCG治疗）的LUF综合征不育妇女中的作用。皮下施用G-CSF（来诺格司亭，100 Fig）。在给予G-CSF与排卵诱导剂联合使用的周期（即G-CSF治疗周期）和仅给予排卵诱导剂的后续周期（即G-CSF）之间比较LUF综合征的发作CSF非治疗控制周期）。结果显示，LUF综合征在G-CSF治疗周期中仅3个周期复发（4.4％（3/68周期）），而LUF综合征在随后的G-CSF非治疗控制周期中13个周期复发（19.1％（13） / 68个周期））。 G-CSF的额外使用可显着防止排卵诱导期间LUF综合征的发生（P = 0.013，McNemar测试）。由于施用G-CSF，未观察到严重的不良反应。总之，我们的发现表明，G-CSF可能成为LUF综合征的有用疗法。

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