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首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >High-density lipoprotein and inflammation in cardiovascular disease
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High-density lipoprotein and inflammation in cardiovascular disease

机译：高密度脂蛋白与心血管疾病的炎症

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摘要

Great advances are being made at the mechanistic level in the understanding of the structural and functional diversity of high-density lipoprotein (HDL). HDL particle subspecies of different sizes are now known to differ in the protein and lipid cargo they transport, conferring on them the ability to perform different functions that in aggregate would be expected to provide protection against the development of atherosclerosis and its downstream clinical consequences. Exacerbating what is already a very complex system is the finding that inflammation, via alteration of the proteomic and lipidomic composition of HDL subspecies, can modulate at least some of their functional activities. In contrast to the progress being made at the mechanistic level, HDL epidemiologic research has lagged behind, largely because the simple HDL biomarkers used (mainly just HDL cholesterol) lack the needed complexity. To address this deficiency, analyses will need to use multiple HDL subspecies and be conducted in such a way as to eliminate potential sources of confounding. To help account for the modulating influence of inflammation, effective use must also be made of inflammatory biomarkers including searching systematically for HDL-inflammation interactions. Using nuclear magnetic resonance (NMR)-measured HDL subclass data and a novel NMR-derived inflammatory biomarker, GlycA, we offer a case study example of the type of analytic approach considered necessary to advance HDL epidemiologic understanding.
机译：在机械水平上对高密度脂蛋白（HDL）的结构和功能多样性的理解方面取得了巨大的进步。现在已知大小不同的HDL颗粒亚种在其运输的蛋白质和脂质货物方面有所不同，赋予它们执行不同功能的能力，这些功能合起来有望为动脉粥样硬化的发展及其下游临床后果提供保护。加剧本来非常复杂的系统的发现是，通过改变HDL亚种的蛋白质组和脂质组学组成，炎症至少可以调节其某些功能活动。与在机制水平上取得的进展相反，HDL流行病学研究落后了，主要是因为所使用的简单HDL生物标记物（主要是HDL胆固醇）缺乏所需的复杂性。为了解决此不足，分析将需要使用多个HDL亚种，并且以消除潜在混杂因素的方式进行分析。为了帮助解释炎症的调节作用，还必须有效利用炎症生物标志物，包括系统地搜索HDL-炎症相互作用。我们使用核磁共振（NMR）测量的HDL亚类数据和新颖的NMR衍生的炎性生物标记物GlycA，提供了一个案例研究示例，该案例被认为是提高HDL流行病学认识所必需的分析方法类型。

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