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首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >Adolescent cholesterol metabolism predicts coronary risk factors at middle age: the Cardiovascular Risk in Young Finns Study.
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Adolescent cholesterol metabolism predicts coronary risk factors at middle age: the Cardiovascular Risk in Young Finns Study.

机译：青少年胆固醇代谢可预测中年人的冠心病危险因素：年轻芬兰人的心血管风险研究。

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Atherosclerosis develops at an early age. We studied whether cholesterol metabolism in adolescence is related to coronary risk factors later during the adult years. A random population sample of 12-year-old (n=162), 15-year-old (n=158), and 18-year-old (n=148) boys who participated in the Cardiovascular Risk in Young Finns Study was studied for major coronary risk factors in 1980 and 2001. These values were related to noncholesterol sterols and their quartiles in 1980 (ie, markers of cholesterol absorption and synthesis). In 1980, serum triglycerides, body mass index (BMI), and systolic blood pressure were lower and high-density lipoprotein (HDL) cholesterol was higher in high absorbers versus low absorbers. This difference, except HDL cholesterol, was maintained after follow-up (eg, in 2001, systolic blood pressure was 123+/-1 mm Hg in low absorbers vs 119+/-1 mm Hg in high absorbers, P<0.01). Cholesterol synthesis (r = up to 0.470, P<0.001) and absorption (r = down to -0.347, P<0.001) were related toBMI at baseline and after follow-up. Significant associations were also found between cholesterol metabolism and serum triglycerides, blood pressure, and HDL cholesterol after follow-up. Cholesterol absorption was related to LDL cholesterol only in low absorbers (r=0.251, P<0.01). In conclusion, synthesis and absorption of cholesterol measured with serum noncholesterol sterols in adolescence were related to coronary risk factors later in adult life. High synthesis and low absorption of cholesterol are related to risk factors that determine the characteristics of the metabolic syndrome.
机译：动脉粥样硬化发展较早。我们研究了在成年后期，青春期的胆固醇代谢是否与冠心病危险因素有关。随机抽取了参加年轻芬兰人心血管风险研究的12岁（n = 162），15岁（n = 158）和18岁（n = 148）男孩的人群样本。在1980年和2001年研究了主要的冠心病危险因素。这些值与1980年的非胆固醇固醇及其四分位数有关（即胆固醇吸收和合成的标志物）。 1980年，高吸收者与低吸收者相比，血清甘油三酸酯，体重指数（BMI）和收缩压降低，高密度脂蛋白（HDL）胆固醇升高。除HDL胆固醇外，这种差异在随访后得以维持（例如，在2001年，低吸收者的收缩压为123 +/- 1 mm Hg，高吸收者的收缩压为119 +/- 1 mm Hg，P <0.01）。基线时和随访后，胆固醇的合成（r =最高至0.470，P <0.001）和吸收（r =最低至-0.347，P <0.001）与BMI有关。随访后还发现胆固醇代谢与血清甘油三酸酯，血压和HDL胆固醇之间存在显着关联。胆固醇的吸收仅在低吸收者中与LDL胆固醇有关（r = 0.251，P <0.01）。总之，青春期用血清非胆固醇固醇测量的胆固醇的合成和吸收与成年后期冠心病危险因素有关。胆固醇的高合成和低吸收与确定代谢综合征特征的危险因素有关。

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