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首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >CD147 expression as a significant prognostic factor in differentiated thyroid carcinoma.
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CD147 expression as a significant prognostic factor in differentiated thyroid carcinoma.

机译：CD147表达是分化型甲状腺癌的重要预后因素。

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摘要

CD147 is 1 of the molecules involved in regulating the expression of matrix metalloproteinases (MMPs). The goal of this study was to analyze the expression of CD147 in differentiated thyroid carcinoma (DTC) tissues as well as its association with the clinicopathologic features of DTC patients and its prognostic significance. During our research, CD147 expression in 156 patients who underwent operation for DTC [100 with papillary thyroid carcinoma (PTC) and 56 with follicular thyroid carcinoma (FTC)] were examined by immunostaining on paraffin-embedded tumor specimens. Then, the association of CD147 expression with clinicopathologic characteristics and patients' prognosis was analyzed. As a result, CD147 was expressed in cancerous lesions but not in normal tissues. Overall, 55 of 156 (35.26%) cases showed low CD147-positive expression, 52 of 156 (33.33%) showed intermediate CD147-positive expression, and 49 of 156 (31.41%) showed high CD147-positive expression. Positive CD147 staining was associated significantly with various clinicopathologic features, such as extrathyroidal invasion (P = 0.02), lymph node metastasis (P = 0.01), and depth of tumor invasion (P < 0.01). Patients with low CD147 expression showed better survival rates than those with intermediate and high expression (90.91% for low expression, 82.69% for intermediate expression, and 65.31% in high expression, respectively; P < 0.05 for analyses). Using Cox regression analysis of the 156 patients, high expression of CD147, extrathyroidal invasion, lymph node metastasis, and the pathologic grading of tumor invasion seemed to be independent prognostic indicators (P < 0.01, P = 0.02, P < 0.01, and P < 0.01, respectively). Therefore, we conclude that the expression of CD147 may be useful to predict the prognosis of DTC patients.
机译：CD147是参与调节基质金属蛋白酶（MMP）表达的分子之一。这项研究的目的是分析CD147在分化的甲状腺癌（DTC）组织中的表达及其与DTC患者的临床病理特征的关系及其预后意义。在我们的研究中，通过对石蜡包埋的肿瘤标本进行免疫染色，检查了156例接受DTC手术的患者中CD147的表达[100例乳头状甲状腺癌（PTC）和56例滤泡性甲状腺癌（FTC）]。然后，分析了CD147表达与临床病理特征和患者预后的关系。结果，CD147在癌性病变中表达，但在正常组织中不表达。总体而言，156例中的55例（35.26％）显示出低的CD147阳性表达，156例中的52例（占33.33％）显示出中等的CD147阳性表达，156例中的49例（31.41％）显示出高CD147阳性表达。 CD147阳性染色与各种临床病理特征显着相关，例如甲状腺外侵犯（P = 0.02），淋巴结转移（P = 0.01）和肿瘤浸润深度（P <0.01）。 CD147低表达的患者比中，高表达的患者具有更高的生存率（低表达的患者为90.91％，中间表达的患者为82.69％，高表达的患者为65.31％;分析的P <0.05）。使用Cox回归分析的156例患者中，CD147的高表达，甲状腺外侵犯，淋巴结转移和肿瘤浸润的病理分级似乎是独立的预后指标（P <0.01，P = 0.02，P <0.01和P < 0.01）。因此，我们得出结论，CD147的表达可能有助于预测DTC患者的预后。

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