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首页> 外文期刊>Transactions of the American Ophthalmological Society. >SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FOR GLAUCOMA (AN AOS THESIS)
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SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FOR GLAUCOMA (AN AOS THESIS)

机译：青光眼的光谱域光学相干断层扫描（AOS论文）

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Purpose: Optical coherence tomography (OCT) is a rapidly evolving, robust technology that has profoundly changed the practice of ophthalmology. Spectral domain OCT (SD-OCT) increases axial resolution 2- to 3-fold and scan speed 60- to 110-fold vs time domain OCT (TD-OCT). SD-OCT enables novel scanning, denser sampling, and 3-dimensional imaging. This thesis tests my hypothesis that SD-OCT improves reproducibility, sensitivity, and specificity for glaucoma detection. Methods: OCT progress is reviewed from invention onward, and future development is discussed. To test the hypothesis, TD-OCT and SD-OCT reproducibility and glaucoma discrimination are evaluated. Forty-one eyes of 21 subjects (SD-OCT) and 21 eyes of 21 subjects (TD-OCT) are studied to test retinal nerve fiber layer (RNFL) thickness measurement reproducibility. Forty eyes of 20 subjects (SD-OCT) and 21 eyes of 21 subjects (TD-OCT) are investigated to test macular parameter reproducibility. For both TD-OCT and SD-OCT, 83 eyes of 83 subjects are assessed to evaluate RNFL thickness and 74 eyes of 74 subjects to evaluate macular glaucoma discrimination. Results: Compared to conventional TD-OCT, SD-OCT had statistically significantly better reproducibility in most sectoral macular thickness and peripapillary RNFL sectoral measurements. There was no statistically significant difference in overall mean macular or RNFL reproducibility, or between TD-OCT and SD-OCT glaucoma discrimination. Surprisingly, TD-OCT macular RNFL thickness showed glaucoma discrimination superior to SD-OCT. Conclusions: At its current development state, SD-OCT shows better reproducibility than TD-OCT, but glaucoma discrimination is similar for TD-OCT and SD-OCT. Technological improvements are likely to enhance SD-OCT reproducibility, sensitivity, specificity, and utility, but these will require additional development.
机译：目的：光学相干断层扫描（OCT）是一项快速发展的强大技术，已深刻改变了眼科的实践。光谱域OCT（SD-OCT）与时域OCT（TD-OCT）相比，轴向分辨率提高了2到3倍，扫描速度提高了60到110倍。 SD-OCT支持新颖的扫描，更密集的采样和3维成像。本论文检验了我的假设，即SD-OCT可改善青光眼检测的可重复性，敏感性和特异性。方法：从发明开始回顾OCT的进展，并讨论未来的发展。为了检验该假设，评估了TD-OCT和SD-OCT的再现性和青光眼辨别力。研究21位受试者（SD-OCT）的41只眼和21位受试者（TD-OCT）的21只眼，以测试视网膜神经纤维层（RNFL）厚度测量的再现性。研究20位受试者（SD-OCT）的40只眼和21位受试者（TD-OCT）的21只眼以测试黄斑参数可重复性。对于TD-OCT和SD-OCT，评估83位受试者的83只眼以评估RNFL厚度，评估74位受试者的74只眼以评估黄斑性青光眼的辨别力。结果：与传统的TD-OCT相比，SD-OCT在大多数扇形黄斑厚度和乳头周围RNFL扇形测量中具有统计学上更好的重现性。在总体平均黄斑或RNFL再现性或TD-OCT和SD-OCT青光眼辨别之间，没有统计学上的显着差异。令人惊讶的是，TD-OCT的黄斑RNFL厚度显示出优于SD-OCT的青光眼辨别力。结论：在目前的发展状态下，SD-OCT的再现性优于TD-OCT，但对TD-OCT和SD-OCT的青光眼辨别相似。技术上的改进可能会增强SD-OCT的可重复性，敏感性，特异性和实用性，但这些都需要进一步的开发。

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