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首页> 外文期刊>Transactions of the American Ophthalmological Society. >SYMMETRY BETWEEN THE RIGHT AND LEFT EYES OF THE NORMAL RETINAL NERVE FIBER LAYER MEASURED WITH OPTICAL COHERENCE TOMOGRAPHY (AN AOS THESIS)
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SYMMETRY BETWEEN THE RIGHT AND LEFT EYES OF THE NORMAL RETINAL NERVE FIBER LAYER MEASURED WITH OPTICAL COHERENCE TOMOGRAPHY (AN AOS THESIS)

机译：光学相干断层扫描测量正常视网膜神经纤维层左右眼的对称性（AOS论文）

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Purpose: To determine the limits of the normal amount of interocular symmetry in retinal nerve fiber layer (RNFL) thickness measurements obtained with third-generation time domain optical coherence tomography (OCT3). Methods: Both eyes of normal volunteers were scanned using the peripapillary standard and fast RNFL algorithms of OCT3. Results: A total of 108 volunteers were included in the analysis. The mean ± standard deviation (SD) of age of the volunteers was 46.0 ± 15.0 years (range 20-82). Forty-two participants (39%) were male and 66 (61%) were female. Mean RNFL thickness correlated extremely well, with intraclass correlation coefficients of 0.89 for both algorithms (95% confidence interval [CI], 0.84-0.93). The mean RNFL thickness of the right eye measured 1.3 μm thicker than the left on the standard scan (SD 4.7, 95% CI 0.4-2.2, P = .004) and 1.2 μm on the fast scan (SD 5.2, 95% CI 0.1-2.2, P = .026). The 95% tolerance limits on the difference between the mean RNFL thicknesses of right minus left eye was -10.8 and+8.9 μm with the standard scan algorithm and-10.6 and+11.7 μm with the fast scan algorithm. Conclusions: Mean RNFL thickness between the 2 eyes of normal individuals should not differ by more than approximately 9 to 12 μm, depending on which scanning algorithm of OCT3 is used and which eye measures thicker. Differences beyond this level suggest statistically abnormal asymmetry, which may represent early glaucomatous optic neuropathy.
机译：目的：确定使用第三代时域光学相干断层扫描（OCT3）获得的视网膜神经纤维层（RNFL）厚度测量中正常眼内对称度的限制。方法：使用OCT3的视乳头标准和快速RNFL算法扫描正常志愿者的双眼。结果：总共108名志愿者被纳入分析。志愿者年龄的平均±标准偏差（SD）为46.0±15.0岁（范围20-82）。 42名参与者（39％）是男性，而66名参与者（61％）是女性。两种算法的平均RNFL厚度相关性非常好，组内相关系数为0.89（95％置信区间[CI]，0.84-0.93）。右眼的平均RNFL厚度在标准扫描（SD 4.7，95％CI 0.4-2.2，P = .004）上比左眼厚1.3μm，在快速扫描（SD 5.2，95％CI 0.1）上为1.2μm -2.2，P = .026）。右减去左眼的平均RNFL厚度之间的差异的95％公差极限在标准扫描算法下为-10.8和+8.9μm，在快速扫描算法下为-10.6和+11.7μm。结论：正常个体的两只眼睛之间的平均RNFL厚度相差不应超过9至12μm，这取决于使用的是哪种OCT3扫描算法以及哪种眼睛更粗。超过该水平的差异表明统计学上不对称，这可能代表了早期青光眼性视神经病变。

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