...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >Prostate health index vs percent free prostate-specific antigen for prostate cancer detection in men with 'gray' prostate-specific antigen levels at first biopsy: systematic review and meta-analysis
【24h】

Prostate health index vs percent free prostate-specific antigen for prostate cancer detection in men with 'gray' prostate-specific antigen levels at first biopsy: systematic review and meta-analysis

机译：前列腺活检指标与游离前列腺特异性抗原百分率进行首次活检时男性“灰色”前列腺特异性抗原水平的男性前列腺癌检测：系统评价和荟萃分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The most promising approach to improve the specificity of prostate-specific antigen (PSA) test relies on the measurement of different molecular isoforms of PSA in serum. Currently, in men with a total PSA (tPSA) level between 2 and 10 ng/mL, measurement of %fPSA (free to total PSA ratio x100) is used as reflex testing to better distinguish between malignant and benign prostate disease. Recently, Beckman Coulter developed the prostate health index (PHI) and several studies suggested that this test may improve the diagnostic ability of %fPSA. We performed a meta-analysis to evaluate the usefulness of PHI compared with %fPSA in the detection of prostate cancer (PCa) at first biopsy in men with tPSA "gray" levels of 2-10 ng/mL. Data on sensitivity and specificity were extracted from 8 eligible studies. Only observational studies comparing the diagnostic ability of PHI and %fPSA in tPSA range of 2-10 ng/mL were included. A total of 8 studies involving 2969 patients with a tPSA range of 20 ng/mL undergoing first biopsy were included in this meta-analysis. Biopsy-confirmed PCa was detected in 1287 (43.3%) men. Selected studies determined both PHI and %fPSA as a reflex test. The areas under curve (AUCs) of PHI and %fPSA were 0.74 (95% confidence interval (CI), 0.70-0.77) and 0.63 (95% CI, 0.58-0.67), respectively. Meta-regression analysis confirmed the superiority of PHI which showed, compared with %fPSA, a relative diagnostic odds ratio of 2.81 (95% CI, 2.19-3.6; P < 0.0001). In conclusion, PHI instead of %fPSA as a reflex test in men with tPSA "gray" levels is a better predictor of positive first biopsy and can offer a reduction in unnecessary biopsies.
机译：改善前列腺特异性抗原（PSA）检测特异性的最有前途的方法取决于血清中PSA的不同分子同工型的测量。目前，在总PSA（tPSA）水平在2到10 ng / mL之间的男性中，％fPSA的测量值（游离PSA与总PSA之比x100）被用作反射测试，以更好地区分恶性和良性前列腺疾病。最近，贝克曼库尔特（Beckman Coulter）开发了前列腺健康指数（PHI），多项研究表明，该测试可以提高％fPSA的诊断能力。我们进行了一项荟萃分析，以评估tPSA“灰色”水平为2-10 ng / mL的男性首次活检时PHI与％fPSA相比在检测前列腺癌（PCa）中的有效性。敏感性和特异性的数据来​​自8项合格研究。只有观察性研究比较了PHI和％fPSA在tPSA 2-10 ng / mL范围内的诊断能力。这项荟萃分析共包括8项研究，涉及2969例tPSA范围为20 ng / mL的患者，首次进行活检。在1287名（43.3％）男性中，经活检证实为PCa。选定的研究将PHI和％fPSA都确定为反射测试。 PHI和％fPSA的曲线下面积（AUC）分别为0.74（95％置信区间（CI），0.70-0.77）和0.63（95％CI，0.58-0.67）。 Meta回归分析证实了PHI的优越性，与％fPSA相比，PHI的相对诊断优势比为2.81（95％CI，2.19-3.6; P <0.0001）。总之，在tPSA“灰色”水平的男性中，用PHI代替％fPSA作为反射测试可以更好地预测首次活检阳性，并且可以减少不必要的活检。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号