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首页> 外文期刊>Transactions of the American Ophthalmological Society. >The reproducibility of ophthalmic utility values.
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The reproducibility of ophthalmic utility values.

机译：眼科实用价值的再现性。

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摘要

PURPOSE: Utility values have been used in the ophthalmic literature to measure the quality of life associated with a health state. By convention, a utility value of 1.0 is associated with perfect health, and a value of 0.0 is associated with death. Construct validity of utility values has been demonstrated, particularly in regard to decreasing utility values as the vision decreases in the better seeing eye, but long-term test-retest reliability has not been demonstrated. The purpose of this study was to demonstrate the test-retest reliability of ophthalmic utility values. METHODS: One hundred fifteen patients with ophthalmic diseases and stable visual acuity underwent time trade-off utility analysis with retesting at various intervals ranging from 1 month to 2 years. The results were analyzed using the Wilcoxon signed rank test. The study was designed to have an 50% power, using a two-sided alpha of 5%, to be able to detect a 10% difference between the test and retest groups. RESULTS: The mean time from testing to retesting was 0.87 years, with a median time of 1.0 year and range of 1 month to 2 years. The mean utility value in the test group was 0.766 (SD = .21; 95% CI, 0.730-0.802), while the mean utility value in the retest group was 0.763 (SD = .22; 95% CI, 0.724-0.802). The difference between the means of the test-retest groups was not significant (P = .99). The intraclass correlation between the initial and follow-up utility scores was .5246 (P < .00005). CONCLUSIONS: Ophthalmic utility values appear to have good test-retest reliability over prolonged periods of time. This information is important because it gives researchers increased confidence in the validity of basic tools for ophthalmic cost-effective (cost-utility) analyses.
机译：目的：在眼科文献中已使用效用值来衡量与健康状况相关的生活质量。按照惯例，效用值为1.0与完美健康相关，而值为0.0与死亡相关。已经证明了效用值的构造效度，尤其是在视力更好的眼睛中视力下降时，降低效用值方面，但尚未证明长期的重测信度。这项研究的目的是证明眼科实用价值的重测可靠性。方法：115名眼科疾病和稳定视力的患者接受了时间权衡效用分析，并在1个月至2年的不同时间间隔进行了重新测试。使用Wilcoxon符号秩检验分析结果。该研究被设计为具有50％的功效，使用5％的双面alpha值，以便能够检测出测试组和再测试组之间10％的差异。结果：从测试到重新测试的平均时间为0.87年，中位时间为1.0年，范围为1个月至2年。测试组的平均效用值为0.766（SD = .21; 95％CI，0.730-0.802），而复测组的平均效用值为0.763（SD = .22; 95％CI，0.724-0.802） 。重测组的平均值之间的差异不显着（P = .99）。初始效用得分和后续效用得分之间的类内相关性为.5246（P <.00005）。结论：眼科实用价值在长时间内似乎具有良好的重测信度。该信息很重要，因为它使研究人员对眼科成本效益（成本效用）分析基本工具的有效性有了更大的信心。

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