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首页> 外文期刊>Transplant immunology >CD8+ T-cell maturation following lung transplantation: the differential impact of CMV and acute rejection.
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CD8+ T-cell maturation following lung transplantation: the differential impact of CMV and acute rejection.

机译：肺移植后CD8 + T细胞成熟：CMV和急性排斥反应的差异影响。

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摘要

Studies on persistent viral infections demonstrate that CD8(+) T-cells differentiate along distinct pathways following chronic antigen exposure; however the effect of stimulation with non-viral chronic antigens is poorly described. We assessed the contributions that the presence of an allograft or cytomegalovirus (CMV) has on the post-thymic differentiation of CD8(+) T-cells in both the blood and lung allograft in patients undergoing lung transplantation. CD28 expression on blood CD8(+) T-cells was reduced in CMV seropositive patients, and was further reduced following acute episodes of CMV reactivation. These viral-associated changes in phenotype were not seen in CD8(+) T-cells isolated from the lung allograft where a different pattern of CD28 expression was observed. Following transplantation there was a progressive reduction in CD28 expression on BAL CD8(+) T-cells. In contrast to what was observed in peripheral blood, reduced CD28 expression on BAL CD8(+) T-cells was associated with a reduced gamma-IFN production. Furthermore, a high proportion of CD28-CD8(+) T-cells in the BAL was associated with fewer episodes of acute allograft rejection. An expanded CD28-CD8(+) T-cell subset, with reduced function, within the lung allograft may have important prognostic implications in lung transplant recipients.
机译：对持续性病毒感染的研究表明，CD8（+）T细胞在长期暴露于抗原后会沿着不同的途径分化。然而，用非病毒性慢性抗原刺激的效果描述得很少。我们评估了同种异体移植物或巨细胞病毒（CMV）的存在对肺移植患者血液和肺同种异体移植物中CD8（+）T细胞的胸腺后分化的贡献。在CMV血清反应阳性的患者中，血液CD8（+）T细胞上的CD28表达降低，而在CMV重新激活的急性发作后进一步降低。这些病毒相关的表型变化在从同种异体肺移植物中分离出的CD8（+）T细胞中未观察到，其中观察到了不同的CD28表达模式。移植后，BAL CD8（+）T细胞的CD28表达逐渐减少。与在外周血中观察到的相反，BAL CD8（+）T细胞上CD28表达的减少与γ-IFN产生的减少有关。此外，BAL中高比例的CD28-CD8（+）T细胞与较少的急性同种异体移植排斥相关。同种异体肺内扩大的功能减弱的CD28-CD8（+）T细胞亚群可能对肺移植受者具有重要的预后影响。

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