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首页> 外文期刊>Transfusion and apheresis science: official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis >A simple screening tool allowing a zero tolerance approach to blood transfusion requests with incomplete special requirement information following a series of incidents
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A simple screening tool allowing a zero tolerance approach to blood transfusion requests with incomplete special requirement information following a series of incidents

机译：一个简单的筛选工具，允许对一系列输血事件采取零容忍的输血要求，并在一系列事件后获得不完整的特殊要求信息

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摘要

Transfusion associated graft versus host disease (TaGVHD) is a potential complication of transfusion of any blood component containing viable T-lymphocytes when there is disparity in the histocompatibility antigens between donor and recipient. This immunological assault is manifested clinically by dysfunction of the skin, liver, gastrointestinal tract and bone marrow, seen 4-30 days after transfusion. Treatment is rarely effective and death is the usual outcome [1]. By inactivating immunologically competent cells using gamma irradiation, TaGVHD can be prevented. Guidelines exist for the use of irradiated products for specific clinical indications in order to prevent the development of TaGVHD (British Committee for Standards in Haematology Blood Transfusion Task Force, 2010). Interestingly, only one case of TaGvHD was reported to our national haemovigilance scheme since the introduction of universal leukodepletion in 1999 [2]. No report of TaGVHD has been received since 2001 and this is despite a large number of clinical incidents every year where non-irradiated components were given in error. This implies that prestorage leukodepletion has significantly reduced, if not abolished, the risk of TaGVHD.
机译：当供体和受体之间的组织相容性抗原存在差异时，与输血相关的移植物抗宿主病（TaGVHD）是任何含有活T淋巴细胞的血液成分输血的潜在并发症。这种免疫性攻击在临床上表现为输血后4-30天出现的皮肤，肝脏，胃肠道和骨髓功能异常。治疗很少见效，死亡是通常的结果[1]。通过使用伽玛射线灭活具有免疫功能的细胞，可以预防TaGVHD。已有针对特定临床适应症使用辐照产品的指南，以防止发展TaGVHD（英国血液学输血标准委员会，2010年）。有趣的是，自1999年实施全白细胞清除术以来，仅1例TaGvHD被报告给我们的国家血液警戒计划[2]。自2001年以来，没有收到TaGVHD的报告，尽管每年都有大量的临床事件，其中未辐照的成分被错误地给予。这意味着存储前白细胞清除术可以显着降低TaGVHD的风险（如果没有废除的话）。

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