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首页> 外文期刊>Transfusion medicine and hemotherapy: offizielles Organ der Deutschen Gesellschaft fur? Transfusionsmedizin und Immunham?atologie >The Blood Group A Genotype Determines the Level of Expression of the Blood Group A on Platelets But Not the Anti-B Isotiter
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The Blood Group A Genotype Determines the Level of Expression of the Blood Group A on Platelets But Not the Anti-B Isotiter

机译:血型A基因型决定了血型A在血小板上的表达水平,但不能决定抗B等位基因的水平

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摘要

Background: The extent of expression of the blood group A on platelets is controversial. Further, the relation between platelets' blood group A expression and the titers of isoagglutinins has not been thoroughly investigated, so far. Methods: We evaluated the relation between the genotype with platelets' blood group A and H expression estimated by flow cytometry and the titers of isoagglutinins. Results: The A expression varied between genotypes and within genotypes. However, the expression in A(1) was stronger than in all other genotypes (p < 0.0001). An overlap of expression levels was apparent between homozygous A(1)A(1) and heterozygous A(1) individuals. Still, The A(1)A(1) genotype is associated with a particularly high antigen expression (p = 0.009). Platelets' A expression in A(2) versus blood group O donors was also significant (p = 0.007), but there was again an overlap of expression. The secretor status had only little influence on the expression (p = 0.18). Also, isoagglutinin titers were not associated with genotypes. Conclusion: To distinguish between A(1) and A(2) donors may reduce incompatible platelet transfusions and therefore be favorable on platelet transfusion increment. Clinical data are needed to support this notion.
机译:背景:血小板中A型血型的表达程度存在争议。此外,到目前为止,尚未充分研究血小板的A血型表达与异凝集素滴度之间的关系。方法:我们通过流式细胞术评估了血小板血型A和H表达的基因型与异凝集素滴度之间的关系。结果:A表达在基因型之间和基因型内变化。但是,A(1)中的表达强于所有其他基因型(p <0.0001)。纯合A(1)A(1)和杂合A(1)个体之间表达水平的重叠是显而易见的。尽管如此,A(1)A(1)基因型仍与特别高的抗原表达相关(p = 0.009)。 A(2)与O型血供体中血小板A的表达也很显着(p = 0.007),但是表达再次重叠。分泌者状态对表达的影响很小(p = 0.18)。同样,异凝集素滴度与基因型无关。结论:区分A(1)和A(2)供体可以减少不相容的血小板输注,因此有利于血小板输注的增加。需要临床数据来支持该观点。

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