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首页> 外文期刊>Transfusion: The Journal of the American Association of Blood Banks >Total nucleated cells as a sole predictor of distinct targets of hematopoietic potential (CD34+ cells) in cord blood units: The results of a large series analysis in autologous cord blood units
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Total nucleated cells as a sole predictor of distinct targets of hematopoietic potential (CD34+ cells) in cord blood units: The results of a large series analysis in autologous cord blood units

机译：总有核细胞是脐带血单位中造血潜能（CD34 +细胞）独特靶标的唯一预测因子​​：自体脐带血单位的大系列分析结果

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Background Rapid identification of eligible cord blood units (CBUs) for banking is an important issue in hematopoietic stem cell procurement. Distinct contents of CD34+ cells in CBU can contribute to identify grafts that may be banked also for unrelated transplants or limited to family-directed or autologous use. Study Design and Methods Considering thresholds of CD34+ cell content of 3 × 106, 2 × 106, and 1 × 106 CD34+ cells, we analyzed a consecutive series of 1309 CBUs. CBUs were collected for autologous banking without any volume-based preselection criteria. Predictors of distinct content of CD34+ cells have been assessed by receiver operating characteristic (ROC) curve analysis. Results Median total nucleated cell (TNC) and CD34+ cell counts of the series were 6.97 × 108 (range, 0.36 × 108-34.9 × 108) and 1.47 × 106 (0-20.56 × 106). Volumes ranged from 21 to 163 mL, with a median of 73.8 mL. For the CD34+ target of 1 × 106, the best predictor was TNC count with a threshold of 6.63 × 108; volume results were less predictive with a value of 68.1 mL. For CD34+ targets of 2 × 106 and 3 × 106, ROC curves confirmed a stronger predictive power of TNC, above the collected volume, with thresholds of 7.55 × 108 and 8.98 × 10 8. ROC analysis by combining all predictors (TNC, volume, TNC 2, volume2, age of mothers, types of delivery, birthweight) gave worse results than TNC count alone. Conclusions This analysis, carried out on a large, unrestricted CBU series, shows that TNC alone is the best predictor of distinct targets of hematopoietic potential with the chance to predict CBU potentially useful for unrelated recipients or limited for family-directed or autologous use.
机译：背景技术快速鉴定合格的脐带血单位（CBU）以用于银行业务是造血干细胞采购中的重要问题。 CBU中CD34 +细胞的不同含量可有助于鉴定也可用于无关的移植或仅限于家族指导或自体使用的移植物。研究设计和方法考虑到3×106、2×106和1×106 CD34 +细胞的CD34 +细胞含量阈值，我们分析了连续的1309个CBU系列。收集CBU进行自体银行业务，没有任何基于数量的预选标准。已通过接收器工作特征（ROC）曲线分析评估了CD34 +细胞不同含量的预测因子。结果该系列的中值总有核细胞（TNC）和CD34 +细胞计数为6.97×108（范围为0.36×108-34.9×108）和1.47×106（0-20.56×106）。体积范围从21到163 mL，中位数为73.8 mL。对于CD34 +靶标为1×106，最好的预测指标是TNC计数，阈值为6.63×108。体积结果的预测性较差，值为68.1 mL。对于2×106和3×106的CD34 +靶标，ROC曲线证实了TNC的较强预测能力，高于所收集的体积，阈值分别为7.55×108和8.98×10 8.通过组合所有预测变量（TNC， TNC 2，第2卷，母亲的年龄，分娩类型，出生体重）比单独使用TNC计数的结果差。结论对大型，无限制的CBU系列进行的分析表明，单独使用TNC可以最好地预测造血潜能的不同靶标，并有机会预测CBU可能对无关的接受者有用，或者仅对家庭指导或自体使用有用。

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