Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging

Sophocleous Reece A.; Mullany Phillip R. F.; Winter Kelly M.; Marks Denese C.; Sluyter Ronald

首页> 外文期刊>Transfusion: The Journal of the American Association of Blood Banks >Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging

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Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging

机译：在体内或离体衰老过程中，红细胞经历P2X7受体介导的磷脂酰丝氨酸暴露的倾向不会改变

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BACKGROUND: Phosphatidylserine (PS) exposure facilitates the removal of red blood cells (RBCs) from the circulation, potentially contributing to the loss of stored RBCs after transfusion, as well as senescent RBCs. Activation of the P2X7 receptor by extracellular adenosine 5'-triphosphate (ATP) can induce PS exposure on freshly isolated human RBCs, but whether this process occurs in stored RBCs or changes during RBC aging is unknown.

机译：背景：磷脂酰丝氨酸（PS）暴露有助于从循环中去除红细胞（RBC），可能导致输血后储存的RBC以及衰老的RBC丢失。细胞外5'-三磷酸腺苷（ATP）激活P2X7受体可以诱导新鲜分离的人RBC暴露PS，但是尚不清楚此过程是否在储存的RBC中发生或在RBC老化过程中发生变化。

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《Transfusion: The Journal of the American Association of Blood Banks》 |2015年第8期|共9页
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Sophocleous Reece A.; Mullany Phillip R. F.; Winter Kelly M.; Marks Denese C.; Sluyter Ronald;
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正文语种 eng
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1. Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging [J] . Sophocleous Reece A., Mullany Phillip R. F., Winter Kelly M., Transfusion: The Journal of the American Association of Blood Banks . 2015,第8期

机译：在体内或离体衰老过程中，红细胞经历P2X7受体介导的磷脂酰丝氨酸暴露的倾向不会改变
2. Physiologically aged red blood cells undergo erythrophagocytosis in vivo but not in vitro [J] . Yehonatan Gottlieb, Orit Topaz, Lyora A. Cohen, Haematologica . 2012,第7期

机译：生理老化的红细胞在体内而非体外经历红细胞吞噬
3. Identification of growth factor conditions that reduce ex vivo cord blood progenitor expansion but do not alter human repopulating cell function in vivo | Haematologica [J] . K Levac, F Karanu, M Bhatia Haematologica . 2005,第2期

机译：鉴定可减少离体脐血祖细胞扩增但不改变体内人繁殖细胞功能的生长因子条件血液学
4. Fluorescence in vivo imaging of live tumor cells with pH-activatable targeted probes via receptor-mediated endocytosis [C] . Daisuke Asanuma, Yasuteru Urano, Tetsuo Nagano, Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications . 2009

机译：通过受体介导的内吞作用用pH激活的靶向探针对活体肿瘤细胞进行荧光体内成像
5. Identifying and Characterizing Red Blood Cell Microvesiculation, Phosphatidylserine and CD47 Expression As a Predictor of Red Blood Cell In Vitro Quality Following Hypothermic Storage. [D] . Almizraq, Ruqayyah Jassim. 2013

机译：鉴定和表征红细胞微囊化，磷脂酰丝氨酸和CD47表达是低温保存后红细胞体外质量的预测指标。
6. 4.1R-deficient human red blood cells have altered phosphatidylserine exposure pathways and are deficient in CD44 and CD47 glycoproteins [O] . Kris P. Jeremy, Zoe E. Plummer, David J. Head, 2009

机译：4.1R缺陷的人类红细胞改变了磷脂酰丝氨酸的暴露途径并且CD44和CD47糖蛋白缺乏
7. Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging [O] . Sophocleous, Reece A, Mullany, Phillip R.F, Winter, Kelly M, 2015

机译：在体内或离体衰老过程中，红细胞发生P2X7受体介导的磷脂酰丝氨酸暴露的倾向不会改变
8. Effects of Oxidative Damage on In Vivo Aging, Density, and Survival of Baboon Red Blood Cells [R] . McKenney, J. B. , Valeri, C. R. , Giorgio, A. , 1992

机译：氧化损伤对狒狒红细胞体内衰老，密度和存活的影响

Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging

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