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首页> 外文期刊>Transfusion: The Journal of the American Association of Blood Banks >MAM: a 'new' high-incidence antigen found on multiple cell lines.
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MAM: a 'new' high-incidence antigen found on multiple cell lines.

机译：MAM：在多种细胞系中发现的“新”高发病率抗原。

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摘要

BACKGROUND: Three women have been identified with an antibody to a "new" high-incidence antigen found on multiple cell lines. CASE REPORTS: The proposita, M.A.M., presented during her third pregnancy with an antibody reacting with all RBCs tested except her own. She delivered a thrombocytopenic infant with a 3+ DAT, but without symptoms of HDN. The second example, A.N., presented during her third pregnancy with an antibody reacting with all RBCs tested except her own and those of M.A.M. She delivered a slightly thrombocytopenic but severely anemic infant. The third example, F.K., a sister of A.N., has an antibody reacting with all RBCs tested except her own and those of M.A.M. and A.N. CONCLUSION: This "new" high-incidence antigen has been named MAM and assigned high-incidence antigen number 901016 by the International Society of Blood Transfusion. The corresponding antibody, anti-MAM, has been shown to cause HDN and has the potential to shorten RBC survival after the transfusion of incompatible RBC units, as determined by monocyte monolayer assay. Immunoblotting and flow cytometry show that this new antibody reacts with various WBC lines in addition to RBCs. This antibody also appears to react with platelets in some assays.
机译：背景：已经鉴定出三名妇女具有针对多种细胞系中发现的“新”高发病率抗原的抗体。病例报告：提案人M.A.M.在她的第三次怀孕期间出现了一种抗体，该抗体与除她自己外的所有RBC都有反应。她分娩了3+ DAT的血小板减少婴儿，但没有HDN症状。第二个例子是A.N.，她在第三次怀孕期间出现了一种抗体，该抗体与除她自己和M.A.M.她分娩了一个轻度血小板减少但贫血严重的婴儿。第三个例子是A.N.的姊妹F.K.，她的抗体与除她自己的和M.A.M.和。结论：这种“新的”高发病率抗原已被国际输血协会命名为MAM，并被指定为高发病率抗原901016。如单核细胞单层测定所确定的，已显示出相应的抗体抗MAM引起HDN，并有可能在输注不相容的RBC单位后缩短RBC存活。免疫印迹和流式细胞仪表明，这种新抗体除与RBC之外，还与各种WBC系发生反应。在某些测定中，该抗体也似乎与血小板反应。

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