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首页> 外文期刊>Transfusion: The Journal of the American Association of Blood Banks >Economic consequences of alterations in platelet transfusion dose: analysis of a prospective, randomized, double-blind trial.
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Economic consequences of alterations in platelet transfusion dose: analysis of a prospective, randomized, double-blind trial.

机译：血小板输注剂量改变的经济后果：一项前瞻性，随机，双盲试验的分析。

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BACKGROUND: In recent years, decreasing financial resources led to the use of lower-dose platelet components. However, the economic consequences of the use of such components have not been carefully studied. STUDY DESIGN AND METHODS: A formal economic analysis was conducted of a recently reported, prospective, randomized, double-blind study examining the platelet dose-response relationship in nonrefractory patients. The economic analysis used a decision analysis model, conducted from the hospital's perspective and based directly on the observed clinical data and on institutional cost structures. RESULTS: The decision analysis model estimated that a 38-percent reduction in mean platelet dose, within the commonly prescribed dose range, would result in the average patient's requiring approximately 60 percent more transfusions in the posttransplant period (8 vs. 5; p = 0.05), which would result in an estimated 60-percent increase in the median cost to the hospital (
机译：背景：近年来，财政资源的减少导致使用低剂量血小板成分。但是，尚未仔细研究使用此类组件的经济后果。研究设计和方法：对最近报道的一项前瞻性，随机，双盲研究进行了正式的经济分析，以检查非难治性患者的血小板剂量-反应关系。经济分析使用了决策分析模型，该模型从医院的角度进行，并直接基于观察到的临床数据和机构成本结构。结果：决策分析模型估计，在通常规定的剂量范围内，平均血小板剂量减少38％将导致平均患者在移植后的期间需要输血约60％（8 vs. 5; p = 0.05） ），这将导致医院的中位数费用估计增加60％（

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