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首页> 外文期刊>Transfusion: The Journal of the American Association of Blood Banks >Transfusion transmission of human T-lymphotropic virus type I (HTLV-I) from an asymptomatic blood donor: conservation of LTR U3, env, and tax nucleotide sequences in a recipient with HTLV-I-associated myelopathy.
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Transfusion transmission of human T-lymphotropic virus type I (HTLV-I) from an asymptomatic blood donor: conservation of LTR U3, env, and tax nucleotide sequences in a recipient with HTLV-I-associated myelopathy.

机译：来自无症状献血者的人类I型T淋巴细胞病毒（HTLV-1）的输血传播：与HTLV-1相关的脊髓病患者的LTR U3，env和tax核苷酸序列的保守性。

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BACKGROUND: Transfusion of human T-lymphotropic virus type I (HTLV-I) contaminated blood is sometimes linked with the rapid onset of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in immunocompromised recipients. STUDY DESIGN AND METHODS: This study addressed the question of whether HTLV-I variants could emerge in an immunocompromised patient who developed HAM/ TSP after the transfusion of blood from an asymptomatic HTLV-I carrier. Base pairs (n = 2327) of the HTLV-I genome located in the LTR U3 region and parts of the env and tax genes were sequenced and compared to the isolated identified in the asymptomatic blood donor and to well-known ATK-1 and H5 strains. The same analysis was performed on another set of samples from an asymptomatic HTLV-I-positive blood donor and a similar blood recipient. RESULTS: No critical changes in nucleotide sequences were identified in the immunosuppressed HAM/TSP patient when compared with the nucleotide sequences of the corresponding blood donor, the other asymptomatic blood donor and recipient or the ATK-1 and H5 strains. CONCLUSION: Immunosuppression does not seem to favor the emergence of particular nucleotide sequences in the genome located in the LTR U3 region or in parts of the env and tax genes in transfused patients who develop HAM/TSP.
机译：背景：输人I型淋巴病毒（HTLV-1）污染的血液有时与免疫功能低下的接受者中HTLV-1相关的脊髓病/热带痉挛性轻瘫（HAM / TSP）的快速发作有关。研究设计和方法：这项研究解决了以下问题：在从无症状HTLV-1载体输血后出现HAM / TSP的免疫受损患者中，是否可能出现HTLV-1变体。对位于LTR U3区域的HTLV-1基因组的碱基对（n = 2327）进行了测序，并对部分env和tax基因进行了测序，并与无症状献血者和已知的ATK-1和H5进行了比较株。对来自无症状HTLV-1阳性供血者和相似受血者的另一组样品进行了相同的分析。结果：与相应献血者，其他无症状献血者和接受者或ATK-1和H5毒株的核苷酸序列相比，在免疫抑制的HAM / TSP患者中没有发现核苷酸序列的关键变化。结论：免疫抑制似乎不支持出现HAM / TSP的输血患者中LTR U3区或部分env和tax基因的基因组中特定核苷酸序列的出现。

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