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首页> 外文期刊>Transfusion: The Journal of the American Association of Blood Banks >Differences in functional activity and antigen expression of granulocytes primed in vivo with filgrastim, lenograstim, or pegfilgrastim.
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Differences in functional activity and antigen expression of granulocytes primed in vivo with filgrastim, lenograstim, or pegfilgrastim.

机译：用非格司亭，雷诺格司亭或聚乙二醇非格司亭在体内引发的粒细胞功能活性和抗原表达的差异。

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摘要

BACKGROUND: Granulocyte-colony-stimulating factor (G-CSF) is known to affect functional activity and antigen expression of neutrophil granulocytes. Beside nonglycosylated filgrastim and glycosylated lenograstim, pegylated filgrastim (pegfilgrastim) has recently been introduced for single administration into clinical use. STUDY DESIGN AND METHODS: Here, granulocytes from 27 patients with nonmyeloid malignancies were compared functionally (migration, reactive oxygen species production, and G-CSF serum levels) and phenotypically (cell surface antigen expression) before and after G-CSF administration. RESULTS: After exposure to G-CSF, chemotaxis was reduced significantly in the filgrastim group. Immunophenotypically, in vivo G-CSF-primed granulocytes were more mature in the lenograstim than in the filgrastim and to lesser extent in the pegfilgrastim groups as shown by the expression profile for CD11b, CD14, and CD16. Of note, G-CSF serum levels were similar among the groups. CONCLUSION: Our data suggest that granulocytes exposed to glycosylated G-CSF in vivo seem to resemble more closely their steady-state phenotype than after treatment with nonglycosylated and to lesser extent pegylated G-CSF.
机译：背景：粒细胞集落刺激因子（G-CSF）已知会影响中性粒细胞粒细胞的功能活性和抗原表达。除了非糖基化非格司亭和糖基化非诺司亭之外，最近还引入了聚乙二醇化非格司亭（pegfilgrastim），可单次给药进入临床。研究设计和方法：在此，比较了在施用G-CSF前后，从功能（迁移，活性氧产生和G-CSF血清水平）和表型（细胞表面抗原表达）方面对27例非髓样恶性肿瘤患者的粒细胞进行了比较。结果：暴露于G-CSF后，非格司亭组的趋化性明显降低。从免疫表型上看，体内G-CSF引发的粒细胞在非诺格司亭中比在非格司亭中成熟，而在pegfilgrastim组中的成熟程度较小，如CD11b，CD14和CD16的表达谱所示。值得注意的是，各组之间的G-CSF血清水平相似。结论：我们的数据表明，在体内暴露于糖基化G-CSF的粒细胞似乎比未糖基化的G-CSF处理程度更小，更接近其稳态表型。

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