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首页> 外文期刊>Transfusion: The Journal of the American Association of Blood Banks >Pediatric apheresis with a novel apheresis device with electronic interface control
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Pediatric apheresis with a novel apheresis device with electronic interface control

机译：带有新型带电子接口控制的采血设备的小儿采血

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BACKGROUND: Cancer in children, and specifically cancer requiring autologous stem cell transplantation, is rare. As a consequence, though, experience with pediatric stem cell apheresis collections is limited. Challenges of apheresis in small children (<20 kg) include small total blood volume, issues with venous access, concerns about tolerable anticoagulant doses, and limitations in product volumes that can safely be collected. STUDY DESIGN AND METHODS: This article presents a small series of autologous "stem cell" apheresis procedures in infants and toddlers weighing between 5.5 and 20 kg, the first ones performed with a novel leukapheresis device (Spectra Optia MNC v.3.0, Terumo BCT) to be reported. Some features of the system are described that can be used to achieve favorable apheresis outcomes in small children. RESULTS: Apheresis procedures were uneventful and successful with similar extraction efficiencies (median preapheresis collection efficiency [CE2], 36%) as in adult patients. At 58%, platelet attrition was considerable. CONCLUSION: Our data indicate that stem cell apheresis with the Spectra Optia MNC v.3.0 in very small donors is feasible, safe, and associated with very small product volumes.
机译：背景：儿童癌症，特别是需要自体干细胞移植的癌症很少见。因此，尽管如此，小儿干细胞单采血液采集的经验有限。幼儿（<20公斤）的血液分离术面临的挑战包括总血液量少，静脉通路问题，对抗凝剂量的耐受性以及可以安全收集的产品量限制。研究设计与方法：本文介绍了一系列针对体重在5.5至20公斤之间的婴幼儿的自体“干细胞”单采程序，第一批程序是使用新型白血球清除仪（Spectra Optia MNC v.3.0，Terumo BCT）进行的。有待报道。描述了该系统的一些功能，这些功能可用于实现幼儿的良好的血液采血效果。结果：与成人患者相比，拔除术的过程顺利且成功，提取效率相似（拔除术前中位收集效率[CE2]为36％）。血小板减少率高达58％。结论：我们的数据表明，在非常小的供体中使用Spectra Optia MNC v.3.0进行干细胞采血是可行，安全的，并且与非常小的产品量相关。

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