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首页> 外文期刊>Trends in biochemical sciences >Are the IKKs and IKK-related kinases TBK1 and IKK-varepsilon similarly activated?
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Are the IKKs and IKK-related kinases TBK1 and IKK-varepsilon similarly activated?

机译：IKK和IKK相关激酶TBK1和IKK-varepsilon是否被类似地激活？

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摘要

The IkappaB kinases (IKKs) IKK-alpha and IKK-beta, and the IKK-related kinases TBK1 and IKK-varepsilon, have essential roles in innate immunity through signal-induced activation of NF-kappaB, IRF3 and IRF7, respectively. Although the signaling events within these pathways have been extensively studied, the mechanisms of IKK and IKK-related complex assembly and activation remain poorly defined. Recent data provide insight into the requirement for scaffold proteins in complex assembly; NF-kappaB essential modulator coordinates some IKK complexes, whereas TANK, NF-kappaB-activating kinase-associated protein 1 (NAP1) or similar to NAP1 TBK1 adaptor (SINTBAD) assemble TBK1 and IKK-varepsilon complexes. The different scaffold proteins undergo similar post-translational modifications, including phosphorylation and non-degradative polyubiquitylation. Moreover, increasing evidence indicates that distinct scaffold proteins assemble IKK, and potentially TBK1 and IKK-varepsilon subcomplexes, in a stimulus-specificmanner, which might be a mechanism to achieve specificity.
机译：IkappaB激酶（IKKs）IKK-alpha和IKK-beta，以及与IKK相关的激酶TBK1和IKK-varepsilon，分别通过信号诱导的NF-kappaB，IRF3和IRF7的激活在先天免疫中起重要作用。尽管已经深入研究了这些途径中的信号转导事件，但对IKK和与IKK相关的复杂组装和激活机制的定义仍不明确。最新数据提供了对复杂组装中支架蛋白需求的见解; NF-κB必需调节剂可协调某些IKK复合物，而TANK，NF-κB激活激酶相关蛋白1（NAP1）或类似于NAP1 TBK1衔接子（SINTBAD）可组装TBK1和IKK-varepsilon复合物。不同的支架蛋白经历相似的翻译后修饰，包括磷酸化和非降解性多泛素化。此外，越来越多的证据表明，不同的支架蛋白以刺激特异性的方式组装了IKK，以及潜在的TBK1和IKK-varepsilon亚复合物，这可能是实现特异性的机制。

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