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首页> 外文期刊>Trends in Cell Biology >The endoplasmic reticulum and protein trafficking in dendrites and axons
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The endoplasmic reticulum and protein trafficking in dendrites and axons

机译:树突和轴突的内质网和蛋白质运输

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摘要

Neurons are highly polarized cells whose dendrites and axons extend long distances from the cell body to form synapses that mediate neuronal communication. The trafficking of membrane lipids and proteins throughout the neuron is essential for the establishment and maintenance of cell morphology and synaptic function. However, the dynamic shape and spatial organization of secretory organelles, and their role in defining neuronal polarity and the composition of synapses, are not well delineated. In particular, the structure and function of the continuous and intricate network of the endoplasmic reticulum (ER) in neurons remain largely unknown. Here we review our current understanding of the ER in dendrites and axons, its contribution to local trafficking of neurotransmitter receptors, and the implications for synaptic plasticity and pathology.
机译:神经元是高度极化的细胞,其树突和轴突从细胞体延伸很长的距离,形成介导神经元通讯的突触。膜脂质和蛋白质在整个神经元中的运输对于建立和维持细胞形态和突触功能至关重要。然而,还没有很好地描述分泌细胞器的动态形状和空间组织,以及它们在定义神经元极性和突触组成中的作用。特别是,神经元内质网(ER)的连续而复杂的网络的结构和功能仍然未知。在这里,我们回顾我们目前对树突和轴突中ER的理解,其对局部神经递质受体运输的贡献以及对突触可塑性和病理学的影响。

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