...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Cardiovascular Medicine >Vascular calcification and fetuin-A deficiency in chronic kidney disease.
【24h】

Vascular calcification and fetuin-A deficiency in chronic kidney disease.

机译：慢性肾脏疾病中的血管钙化和胎球蛋白-A缺乏症。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In past decades, extraosseous (including cardiovascular) calcification was predominantly regarded as a passive process of limited pathophysiological significance. It was thought that a calcium (Ca) x phosphate (P) product in excess of Ca and P solubility was the key trigger of progressive hydroxyapatite precipitation and deposition in vessels and soft tissues. Recently, however, it became apparent that calcification is a complex and highly regulated process involving inhibitors, inducers, and cell differentiation processes. It further became evident that cardiovascular manifestations of calcification predict patient outcomes in general populations, but in particular, in patients with chronic kidney disease. This review discusses the role of fetuin-A in the regulation of extraosseous and especially cardiovascular calcification processes. Fetuin-A is an inflammation-related Ca-regulatory glycoprotein and the prototype of a systemically acting calcification inhibitor. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality.
机译：在过去的几十年中，骨外（包括心血管）钙化被认为是病理生理意义有限的被动过程。人们认为，钙（Ca）x磷酸盐（P）产物的溶解度超过Ca和P，是促使羟磷灰石逐渐沉淀和沉积在血管和软组织中的关键触发因素。然而，最近，很明显钙化是一个复杂且受高度调控的过程，涉及抑制剂，诱导剂和细胞分化过程。进一步变得明显的是，钙化的心血管表现预示了一般人群中的患者结果，但特别是在患有慢性肾脏疾病的患者中。这篇综述讨论了胎球蛋白A在骨外尤其是心血管钙化过程中的作用。 Fetuin-A是一种与炎症相关的Ca调节糖蛋白，是全身性钙化抑制剂的原型。横断面研究表明，胎球蛋白A缺乏症在透析患者中​​作为危险因素的新兴作用证明了其与全因和心血管死亡率的显着相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号