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首页> 外文期刊>Turkish Journal of Veterinary and Animal Sciences >Influence of cyclosporine A and quercetine on MIC values of danofloxacin mesylate in Escherichia coli strains isolated from poultry.
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Influence of cyclosporine A and quercetine on MIC values of danofloxacin mesylate in Escherichia coli strains isolated from poultry.

机译：环孢菌素A和槲皮素对从家禽分离的大肠杆菌菌株甲磺酸达氟沙星的MIC值的影响。

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摘要

A reference strain Escherichia coli ATCC 25922, sensitive and resistant strains of E. coli, isolated from chickens with colibacillosis were tested. The aim of the present study was to determine the effect of modulators of ATP binding casette (ABC) efflux transporters, cyclosporine A and quercetin on minimum inhibitory concentration (MIC) values of danofloxacin mesylate. MIC values of danofloxacine mesylate against the chosen strains were determined with or without modulators at concentrations of 25, 5, 1 and 0.2 micro M by macrobroth dilution method. Results revealed that MIC values decreased from 2-fold to 16-fold in the investigated strains of E. coli. The combination of danofloxacin mesylate and quercetin resulted in an increase of MIC values. The observed changes in the values of MICs suggest participation of ATP-dependent efflux of danofloxacin mesylate from bacterial cells.
机译：参考菌株大肠杆菌ATCC 25922，敏感和耐药菌株。测试了从患有大肠杆菌病的鸡中分离出的大肠杆菌。本研究的目的是确定ATP结合盒（ABC）外排转运蛋白，环孢菌素A和槲皮素的调节剂对甲磺酸达氟沙星的最低抑菌浓度（MIC）值的影响。甲磺酸达氟沙星对所选菌株的MIC值是通过大肉汤稀释法测定的，在有或没有调节剂的情况下，浓度分别为25、5、1和0.2 microM。结果显示，在所研究的E株中，MIC值从2倍降低至16倍。大肠杆菌。甲磺酸达氟沙星和槲皮素的组合导致MIC值增加。 MIC值的观察到的变化表明甲磺酸单氧氟沙星从细菌细胞中参与了ATP依赖的流出。

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