Comparative pharmacokinetics and PK/PD parameters of five aminoglycosides in goats.

Dinev T.; Urumova V.; Lyutskanov M.; Lashev L.

首页> 外文期刊>Turkish Journal of Veterinary and Animal Sciences >Comparative pharmacokinetics and PK/PD parameters of five aminoglycosides in goats.

【24h】

Comparative pharmacokinetics and PK/PD parameters of five aminoglycosides in goats.

机译：山羊中5种氨基糖苷的比较药代动力学和PK / PD参数。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The pharmacokinetics of gentamicin, tobramycin, amikacin, kanamycin, and apramycin were investigated after single intravenous administration in goats (n=6). The antimicrobial activity against 30 strains of Staphylococcus aureus isolates from goats was also studied. All five antibiotics showed a significantly high in vitro antibacterial activity. The lowest MIC₉₀ values were those of amikacin and the highest was of kanamycin. The ratios of Cmax:MIC showed that amikacin had an advantage of providing the highest values of the concentration or MIC₉₀ ratio, as well of the time providing bactericidal levels, followed by apramycin. The other three antibiotics had comparable values, but lower than the first two antibiotics. The same interpretation could be made for the area under the curve or MIC₉₀ ratio.

机译：在山羊（n = 6）单次静脉内给药后，研究了庆大霉素，妥布霉素，阿米卡星，卡那霉素和阿普霉素的药代动力学。还研究了对30株来自山羊的金黄色葡萄球菌分离株的抗菌活性。所有五种抗生素均显示出很高的体外抗菌活性。 MIC _{90 值最低的是阿米卡星，最高的是卡那霉素。 Cmax：MIC的比值表明，丁胺卡那霉素具有提供最高浓度或MIC _{90 比值的优势，并且具有杀菌水平，其次是阿普霉素。其他三种抗生素具有可比较的价值，但低于前两种抗生素。对于曲线下方的面积或MIC _{90 比，可以做出相同的解释。}}}

著录项

来源
《Turkish Journal of Veterinary and Animal Sciences》 |2009年第3期|共6页
作者
Dinev T.; Urumova V.; Lyutskanov M.; Lashev L.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类动物医学（兽医学）;
关键词
amikacin; antibacterial properties; apramycin; drug delivery systems; gentamicin; intravenous injection; kanamycin; pharmacodynamics; pharmacokinetics; pharmacology; potency; tobramycin; goats; Staphylococcus aureus;

机译：阿米卡星;抗菌性能;apramycin;药物递送系统;庆大霉素;静脉注射;卡那霉素;药效学;药代动力学;药理学;效力;妥布霉素;山羊;金黄色葡萄球菌;

相似文献

外文文献
中文文献
专利

1. Comparative pharmacokinetics and PK/PD parameters of five aminoglycosides in goats. [J] . Dinev T., Urumova V., Lyutskanov M., Turkish Journal of Veterinary and Animal Sciences . 2009,第3期

机译：山羊中5种氨基糖苷的比较药代动力学和PK / PD参数。
2. Antibacterial activities and PK/PD parameters of aminoglycosides against recent clinical isolates of gram-negative rods [J] . Okubo T, Iyobe S The Japanese journal of antibiotics . 2002,第5期

机译：氨基糖苷对近期克负杆临床分离株的抗菌活性和PK / PD参数
3. POPULATION PHARMACOKINETIC (PK) AND PHARMACOKINETIC-PHARMACODYNAMIC (PK/PD) ASSESSMENT OF GDC-0334 (A TRPA1 INHIBITOR) IN HEALTHY SUBJECTS. [J] . Chan H., Li H., Liu L., Clinical Pharmacology and Therapeutics . 2020,第S1期

机译：人口药代动力学（PK）和药代动力学药物动力学（PK / PD）对健康受试者的GDC-0334（TRPA1抑制剂）的评估。
4. FPGA Implementation of a Pharmacodynamic and Pharmacokinetics (PK/PD) Model for Application in General Anesthesia [C] . Maria Camila Cardona García, David Alejandro Vallejo Santacruz, Daniel Felipe Valencia Vargas, IEEE ANDESCON Conference . 2018

机译：用于全身麻醉的药效和药代动力学（PK / PD）模型的FPGA实现
5. Mechanism-based pharmacokinetic/pharmacodynamic PK/PD modeling of corticosteroids and antiretrovirals. [D] . Fang, Jing. 2012

机译：皮质类固醇和抗逆转录病毒药物的基于机理的药代动力学/药效动力学PK / PD建模。
6. 2562. Re-Appraisal of Aminoglycoside (AG) Susceptibility Testing Breakpoints Based on the Application of Pharmacokinetics–Pharmacodynamics (PK-PD) and Contemporary Microbiology Surveillance Data [O] . Sujata M Bhavnani, Nikolas J Onufrak, Jeffrey P Hammel, -1

机译：2562.基于药代动力学-药效学（PK-PD）和现代微生物学监测数据的应用对氨基糖苷（AG）药敏试验断点的重新评估
7. Study on PK/PD (Pharmacokinetic/Pharmacodynamic) Parameters for Vancomycin when Used for Elderly Patients Infected with Methicillin-resistant Staphylococcus aureus [O] . Yasuhiro Tsuji, Akiko Mizoguchi, Shiro Tamashima, 2006

机译：用甲氧西林金黄色葡萄球菌感染的老年患者PK / Pd（药代动力学/药物动力学）参数研究

Comparative pharmacokinetics and PK/PD parameters of five aminoglycosides in goats.

摘要

著录项

相似文献

相关主题

期刊订阅