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首页> 外文期刊>Trends in Plant Science >Technical focus: analysis of the N-glycosylation of recombinant glycoproteins produced in transgenic plants
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Technical focus: analysis of the N-glycosylation of recombinant glycoproteins produced in transgenic plants

机译：技术重点：转基因植物中产生的重组糖蛋白的N-糖基化分析

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摘要

The number of therapeutic proteins that have been successfully produced in plants is steadily increasing and is expected to grow rapidly in the future. Most therapeutic proteins are glycoproteins and N-glycosylation is often essential for their stability, folding and biological activity. Recombinant glycoproteins of mammalian origin expressed in transgenic plants largely retain their biological activity. However, N-linked glycan processing differs in plants and mammals and this feature might represent an important limitation to their use. Thus, an improved understanding of protein glycosylation in plants has become crucial to the quality control of these emerging drugs.
机译：在植物中成功产生的治疗性蛋白质的数量正在稳定增长，并有望在未来迅速增长。大多数治疗性蛋白质是糖蛋白，而N-糖基化通常对于它们的稳定性，折叠性和生物活性至关重要。在转基因植物中表达的哺乳动物来源的重组糖蛋白在很大程度上保留了其生物学活性。但是，N-连接的聚糖加工在植物和哺乳动物中有所不同，此功能可能代表了对其使用的重要限制。因此，对植物中蛋白质糖基化的更好理解已成为这些新兴药物质量控制的关键。

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